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Research Output 1994 2019

2019

Direct oral anticoagulant (DOAC)-mediated vasodilation: Role of nitric oxide

Mabley, J., Patel, J., Sayed, A., Arya, R. & Scutt, G., 12 Feb 2019, In : Thrombosis Research. 176, p. 36-38 3 p.

Research output: Contribution to journalLetterResearchpeer-review

Vasodilation
Anticoagulants
Nitric Oxide
Vitamin K
Food-Drug Interactions
2017

Effect of the anti-retroviral drugs efavirenz, tenofovir and entricitabine on endothelial cell function: role of PARP

Faltz, M., Bergin, H., Pilavachi, E., Grimwade, G. & Mabley, J., 3 Jan 2017, In : Cardiovascular Toxicology. p. 1-12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Tenofovir
efavirenz
Poly(ADP-ribose) Polymerases
Endothelial Cells
Pharmaceutical Preparations
2016

Acute paraquat exposure impairs colonic motility by selectively attenuating nitrergic signaling in the mouse

Diss, L., Dyball, S., Ghela, T., Golding, J., Morris, R., Robinson, S., Tucker, R., Walter, T., Young, P., Allen, M., Fidalgo, S., Gard, P., Mabley, J., Patel, B., Chatterjee, P. & Yeoman, M., 30 Jan 2016, In : Autonomic Neuroscience-Basic & Clinical. 195, p. 8-15 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Paraquat
Migrating Myoelectric Complexes
Gastrointestinal Tract
Colon
Myenteric Plexus
2013

Smooth muscle relaxation and activation of the large conductance Ca++ - activated K+ (BKCa) channel by novel oestrogens

Maher, J., Hunter, A. C., Mabley, J., Lippiat, J. D. & Allen, M., 16 Apr 2013, In : British Journal of Pharmacology. 169, 5

Research output: Contribution to journalArticleResearchpeer-review

Muscle Relaxation
Smooth Muscle
Estradiol
Estrogens
HEK293 Cells
2011

Nicotine exerts an anti-inflammatory effect in a murine model of acute lung injury

Mabley, J., Gordon, S. & Pacher, P., 31 Aug 2011, In : Inflammation. 34, 4, p. 231-237 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Lipotoxicity in renal proximal tubular cells: relationship between endoplasmic reticulum stress and oxidative stress pathways

Katsoulieris, E., Mabley, J., Samai, M., Sharpe, M. A., Green, I. C. & Chatterjee, P., 15 Jun 2010, In : Free Radical Biology & Medicine. 48, 12, p. 1654-1662

Research output: Contribution to journalArticleResearchpeer-review

2009

Activation of the cholinergic antiinflammatory pathway reduces ricin-induced mortality and organ failure in mice

Mabley, J., Pacher, P. & Szabo, C., 5 Feb 2009, In : Molecular Medicine. 15, 5-6, p. 166-172 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Alpha-Linolenic acid protects renal cells against palmitic acid lipotoxicity via inhibition of endoplasmic reticulum stress

Katsoulieris, E., Mabley, J., Samai, M., Green, I. C. & Chatterjee, P., 25 Nov 2009, In : European Journal of Pharmacology. 623, 1-3, p. 107-112 6 p.

Research output: Contribution to journalArticleResearchpeer-review

PCB-induced endothelial cell dysfunction: role of poly(ADP-ribose) polymerase

Helyar, S. G., Patel, B., Headington, K., El Assal, M., Chatterjee, P., Pacher, P. & Mabley, J., 15 Oct 2009, In : Biochemical Pharmacology. 78, 8, p. 959-965 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The novel inosine analogue INO-2002 exerts an anti-inflammatory effect in a murine model of acute lung injury

Mabley, J., Pacher, P., Murthy, K. G. K., Williams, W., Southan, G. J., Salzman, A. L. & Szabo, C., Sep 2009, In : Shock. 32, 3, p. 258-262 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy

Rajesh, M., Mukhopadhyay, P., Bátkai, S., Mukhopadhyay, B., Patel, V., Haskó, G., Szabó, C., Mabley, J., Liaudet, L. & Pacher, P., Aug 2009, In : Journal of Cellular and Molecular Medicine. 13, 8b, p. 2330-2341 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Exposure to persistant organic pollutants, polychlorinated biphenyls, potentiates fatty acid-mediated beta cell death: role of ER-stress

Okafor, L., Chadbourn, I., Wale, A., Katsoulieris, E., Cunningham, J., Chatterjee, P. K. & Mabley, J., Sep 2008, In : Diabetologia. 51, S1, p. S226-S226

Research output: Contribution to journalArticleResearchpeer-review

The novel inosine analogue INO-2002 protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type 1 diabetes

Mabley, J., Pacher, P., Murthy, K. G. K., Williams, W., Southan, G. J., Salzman, A. L. & Szabo, C., Sep 2008, In : Journal of Endocrinology. 198, 3, p. 581-589 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Adenosine receptor activation ameliorates type 1 diabetes

Bleich, D., Csóka, B., Nemeth, Z. H., Pacher, P., Mabley, J., Himer, L., Vizi, E. S., Deitch, E. A., Szabo, C., Cronstein, B. N. & Hasko, G., 31 Aug 2007, In : Faseb journal. 21, 10, p. 2379-2388 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Adenosine-5'-(N-ethylcarboxamide)
Purinergic P1 Receptors
Type 1 Diabetes Mellitus
Inbred NOD Mouse
Streptozocin

Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D

Mabley, J., Wallace, R., Pacher, P., Murphy, K. & Szabo, C., Jun 2007, In : International Journal of Molecular Medicine. 19, 6, p. 947-952 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Poly Adenosine Diphosphate Ribose
Vitamin D
Anti-Inflammatory Agents
Calcitriol
Keratinocytes
2006

Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure

Pacher, P., Liaudet, L., Mabley, J., Cziraki, A., Hasko, G. & Szabo, C., 28 Feb 2006, In : International Journal of Molecular Medicine. 17, 2, p. 369-375 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Poly(ADP-ribose) Polymerases
Doxorubicin
Heart Failure
Endotoxins
Ligation
2005

Discovery of potent poly (ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone

Jagtap, P. G., Baloglu, E., Southan, G. J., Mabley, J., Li, H. S., Zhou, J., van Duzer, J., Salzman, A. L. & Szabo, C., 16 Jul 2005, In : Journal of Medicinal Chemistry. 48, 16, p. 5100-5103 4 p.

Research output: Contribution to journalArticleResearch

Poly(ADP-ribose) Polymerases
Sulfonamides
Substitution reactions
Derivatives
Enzymes

Gender differences in the endotoxin-induced inflammatory and vascular responses: potential role of poly(ADP-ribose) polymerase activation

Mabley, J., Horvath, E. M., Murthy, K. G. K., Zsengeller, Z., Vaslin, A., Benko, R., Kollai, M. & Szabo, C., Nov 2005, In : Journal of Pharmacology and Experimental Therapeutics. 315, p. 812-820 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Potential role for 8-oxoguanine DNA glycosylase in regulating inflammation

Mabley, J., Pacher, P., Deb, A., Wallace, R., Elder, R. H. & Szabo, C., Feb 2005, In : Faseb journal. 19, 2, p. 290-292 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst

Obrosova, I. G., Mabley, J., Zsengeller, Z., Charniauskaya, T., Abatan, O. I., Groves, J. T. & Szabo, C., Mar 2005, In : Faseb journal. 19, 3, p. 401-403 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies

Pacher, P., Obrosova, I. G., Mabley, J. & Szabo, C., 2005, In : Current Medicinal Chemistry. 12, 3, p. 267-275 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic vascular dysfunction

Mabley, J. & Soriano, F. G., 31 Jul 2005, In : Current Vascular Pharmacology. 3, 3, p. 247-252 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Poly(ADP-ribose) Polymerases
Hyperglycemia
Blood Vessels
Nitric Oxide
Endothelial Cells
2004

Activation of poly(ADP-ribose) polymerase in circulating leukocytes during myocardial infarction

Murthy, K. G. K., Xiao, C. Y., Mabley, J., Chen, M. & Szabo, C., Mar 2004, In : Shock. 21, 3, p. 230-234 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Poly(ADP-ribose) Polymerases
Myocardial Reperfusion
Leukocytes
Myocardial Infarction
Myocardial Ischemia

A new, potent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced aging

Pacher, P., Vaslin, A., Benko, R., Mabley, J., Liaudet, L., Hasko, G., Marton, A., Batkai, S., Kollai, M. & Szabo, C., Nov 2004, In : Journal of Pharmacology and Experimental Therapeutics. 311, p. 485-491 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation

Szabo, C., Pacher, P., Zsengeller, Z., Vaslin, A., Komjati, K., Benko, R., Chen, M., Mabley, J. & Kollai, M., 2004, In : Molecular Medicine. 10, 1-6, p. 28-35 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma

Virag, L., Bai, P., Bak, I., Pacher, P., Mabley, J., Liaudet, L., Bakondl, E. & Gergely, P., 2004, In : Medical Science Monitor. 10, 3, p. 77-83 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis

Murakami, K., Enkhbaatar, P., Shimoda, K., Cox, R. A., Burke, A. S., Hawkins, H. K., Traber, L. D., Schmalstieg, F. C., Salzman, A. L., Mabley, J., Komjati, K., Pacher, P., Zsengeller, Z., Szabo, C. & Traber, D. L., Feb 2004, In : Shock. 21, 2, p. 126-133 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure

Pacher, P., Mabley, J., Liaudet, L., Evgenov, O. V., Marton, A., Hasko, G., Kollai, M. & Szabo, C., Jul 2004, In : American Journal of Physiology - Heart and Circulatory Physiology. 287, p. 2132-2137 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Matrix metalloproteinase activation is an early event in doxorubicin-induced cardiotoxicity

Bai, P., Mabley, J., Liaudet, L., Virag, L., Szabo, C. & Pacher, P., 2004, In : Oncology Reports. 11, 2, p. 505-508 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Poly(ADP-ribose) polymerase inhibition protects neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke

Komjati, K., Mabley, J., Virag, L., Southan, G. J., Salzman, A. L. & Szabo, C., Mar 2004, In : International Journal of Molecular Medicine. 13, 3, p. 373-382 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Suppression of intestinal polyposis in Apcmin/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways

Mabley, J., Pacher, P., Bai, P., Wallace, R., Goonesekera, S., Virag, L., Southan, G. J. & Szabo, C., Apr 2004, In : Mutation research - fundamental and molecular mechanisms of mutagenesis. 548, 1-2, p. 107-116 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Intestinal Polyposis
Poly Adenosine Diphosphate Ribose
Nitric Oxide
Reactive Nitrogen Species
Oxidative Stress

The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1)

Jagtap, P., Southan, G. J., Baloglu, E., Ram, E., Mabley, J., Marton, A., Salzman, A. L. & Szabo, C., Jan 2004, In : Bioorganic & Medicinal Chemistry Letters. 14, p. 81-85 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Adenosine
Poly(ADP-ribose) Polymerases
Derivatives
Poly(ADP-ribose) Polymerase Inhibitors
1-oxoisoindole

The Therapeutic Effects of PJ34 [N-(6-Oxo-5,6-dihydrophenanthridin-2-yl) -N,N-dimethylacetamide.HCl], a Selective Inhibitor of Poly(ADP-Ribose) Polymerase, in Experimental Allergic Encephalomyelitis Are Associated with Immunomodulation

Scott, G. S., Kean, R. B., Mikheeva, T., Fabis, M. J., Mabley, J., Szabo, C. & Hooper, D. C., Sep 2004, In : Journal of Pharmacology and Experimental Therapeutics. 310, p. 1053-1061 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep

Shimoda, K., Murakami, K., Enkhbaatar, P., Traber, L. D., Cox, R. A., Hawkins, H. K., Schmalstieg, F. C., Komjati, K., Mabley, J., Szabo, C., Salzman, A. L. & Traber, D. L., Jul 2003, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 285, 1, p. 240-249 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis

Liaudet, L., Szabo, C., Evgenov, O. V., Murthy, K. G. K., Pacher, P., Virag, L., Mabley, J., Marton, A., Soriano, F. G., Kirov, M. Y., Bjertnaes, L. J. & Salzman, A. L., Feb 2003, In : Shock. 19, 2, p. 131-137 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Inosine protects against the development of diabetes in multiple-low-dose streptozotocin and nonobese diabetic mouse models of type 1 diabetes

Mabley, J., Rabinovitch, A., Suarez-Pinzon, W. L., Hasko, G., Pacher, P., Power, R., Southan, G. J., Salzman, A. L. & Szabo, C., Mar 2003, In : Molecular Medicine. 9, 3-4, p. 96-104 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Inosine reduces inflammation and improves survival in a murine model of colitis

Mabley, J., Pacher, P., Liaudet, L., Soriano, F. G., Hasko, G., Marton, A., Szabo, C. & Salzman, A. L., Jan 2003, In : American Journal of Physiology-Gastrointestinal and Liver Physiology. 284, 1, p. 138-144 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Parenteral administration of glipizide sodium salt, an inhibitor of adenosine triphosphate-sensitive potassium channels, prolongs short-term survival after severe controlled hemorrhage in rats

Evgenov, O. V., Pacher, P., Williams, W., Evgenov, N. V., Mabley, J., Cicila, J., Siko, J. B., Salzman, A. L. & Szabo, C., Oct 2003, In : Critical Care Medicine. 31, 10, p. 2429-2436 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Poly (ADP-Ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes

Suarez-Pinzon, W. L., Mabley, J., Power, R., Szabo, C. & Rabinovitch, A., Jul 2003, In : Diabetes. 52, 7, p. 1683-1688 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction

Pacher, P., Liaudet, L., Bai, P., Mabley, J., Kaminski, P. M., Virag, L., Deb, A., Szabo, E., Ungvari, Z., Wolin, M. S., Groves, J. T. & Szabo, C., Feb 2003, In : Circulation. 107, 6, p. 896-904 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis

Lohinai, Z., Mabley, J., Feher, E., Marton, A., Komjati, K. & Szabo, C., 2003, In : Journal of Dental Research. 82, 12, p. 987-992 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5′-N-methyluronamide, is protective in two murine models of colitis

Mabley, J., Soriano, F. G., Pacher, P., Hasko, G., Marton, A., Wallace, R., Salzman, A. L. & Szabo, C., Apr 2003, In : European Journal of Pharmacology. 466, 3, p. 323-329 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Adenosine A3 Receptor Agonists
Colitis
Adenosine
Colon
Chemokines

Topical administration of a novel nitric oxide donor, linear polyethylenimine-nitric oxide/nucleophile adduct (DS1), selectively increases vaginal blood flow in anesthetized rats

Pacher, P., Mabley, J., Liaudet, L., Evgenov, O. V., Southan, G. J., Abdelkarim, G. E., Szabo, C. & Salzman, A. L., Dec 2003, In : International Journal of Impotence. 15, 6, p. 461-464 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Polyethyleneimine
Topical Administration
Nitric Oxide Donors
Nitric Oxide
Hemodynamics
2002

Activation of poly(ADP-Ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation

Liaudet, L., Pacher, P., Mabley, J., Virag, L., Soriano, F. G., Hasko, G. & Szabo, C., Feb 2002, In : American Journal of Respiratory and Critical Care Medicine. 165, 3, p. 372-377 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipopolysaccharides
Pneumonia
Chemokines
Lung
Lipid Peroxidation

Activation of poly(ADP-Ribose) polymerase contributes to development of doxorubicin-induced heart failure

Pacher, P., Liaudet, L., Bai, P., Virag, L., Mabley, J., Hasko, G. & Szabo, C., Mar 2002, In : Journal of Pharmacology and Experimental Therapeutics. 300, 3, p. 862-867 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging

Pacher, P., Mabley, J., Soriano, F. G., Liaudet, L. & Szabo, C., Jun 2002, In : International Journal of Molecular Medicine. 9, 6, p. 659-664 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of inflammation, organ damage, and oxidant stress induced by salmonella enterica serovar huenchen flagellin and serovar enteritidis lipopolysaccharide

Liaudet, L., Murthy, K. G. K., Mabley, J., Pacher, P., Soriano, F. G., Salzman, A. L. & Szabo, C., Jan 2002, In : Infection and Immunity. 70, 1, p. 192-198 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelial dysfunction in aging animals: the role of poly(ADP-ribose) polymerase activation

Pacher, P., Mabley, J., Soriano, F. G., Liaudet, L., Komjati, K. & Szabo, C., Mar 2002, In : British Journal of Pharmacology. 135, 6, p. 1347-1350 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Poly(ADP-ribose) Polymerases
Reactive Nitrogen Species
Enzyme Activation
Oxidants
Vasodilation

Inosine exerts a broad range of antiinflammatory effects in a hurine model of acute lung injury

Liaudet, L., Mabley, J., Pacher, P., Virag, L., Soriano, F. G., Marton, A., Hasko, G., Deitch, E. A. & Szabo, C., Apr 2002, In : Annals of Surgery. 235, 4, p. 568-578 11 p.

Research output: Contribution to journalArticleResearchpeer-review