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Scholarly biography

Dr Sheridan graduated from University College Dublin (UCD, Ireland) in 2004 with a BSc honours degree in Pharmacology. He then joined Prof Keith Murphy’s research group in the Conway Institute and received a PhD in Neuroscience from UCD in 2009. His early research focused on the effects of neuroinflammation on learning, memory and synaptic plasticity in the hippocampus region of the brain.

Dr Sheridan then moved to Trinity College Dublin to pursue a postdoctoral fellowship in Prof Kumlesh Dev’s research group in the department of Physiology. Whilst there, he studied the role of sphingosine 1-phosphate receptors in astrocytes and in myelination of the central nervous system (CNS). A major focus of this research was identifying novel drug targets for neuroinflammatory disorders of the CNS, such as Multiple Sclerosis.

In 2012, he joined the department of Physiology, Development and Neuroscience in the University of Cambridge as a postdoctoral research associate. Here, Dr Sheridan investigated the role of stretch-activated ion channels (mechanosensation) in embryonic axon guidance and the influence of cell mechanics in neural regeneration and CNS glial scarring following traumatic brain and spinal cord injuries.

In 2014, Dr Sheridan joined the School of Pharmacy & Biomolecular Sciences and established his research group, the Neuroimmunology & Neurotherapeutics Laboratory. He is also a member of the Centre for Stress and Age-related Disease in the University of Brighton.

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Lysosphingolipid Receptors Medicine & Life Sciences
Neuronal Plasticity Medicine & Life Sciences
Hippocampus Medicine & Life Sciences
Astrocytes Medicine & Life Sciences
Neuroglia Medicine & Life Sciences
Dentate Gyrus Medicine & Life Sciences
Long-Term Potentiation Medicine & Life Sciences
Chemokines Medicine & Life Sciences

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Research Output 2007 2018

Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes

Velasco-Estevez, M., Mampay, M., Boutin, H., Chaney, A., Warn, P., Sharp, A., Burgess, E., Moeendarbary, E., Dev, K. K. & Sheridan, G., 22 Oct 2018, In : Frontiers in Aging Neuroscience. 10, p. 1-18 18 p., 332.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Amyloid Plaques
Alzheimer Disease

Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia

O'Sullivan, S. A., O’Sullivan, C., Healy, L. M., Dev, K. K. & Sheridan, G., 27 Jan 2018, In : Journal of Neurochemistry. 144, 6, p. 736-747

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Lysosphingolipid Receptors

The soft mechanical signature of glial scars in the central nervous system

Moeendarbary, E., Weber, I. P., Sheridan, G., Koser, D. E., Soleman, S., Haenzi, B., Bradbury, E. J., Fawcett, J. & Franze, K., 20 Mar 2017, In : Nature Communications. 8

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Central Nervous System
Wounds and Injuries
Nerve Tissue

Lysophosphatidic acid receptors (LPARs): potential targets for the treatment of neuropathic pain

Velasco, M., O'Sullivan, C. & Sheridan, G., 5 Apr 2016, In : Neuropharmacology. 113, p. 608-617 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Lysophosphatidic Acid Receptors
Demyelinating Diseases

Mechanosensing is critical for axon growth in the developing brain

Kosler, D. E., Thompson, A. J., Foster, S. K., Dwivedy, A., Pillai, E. K., Sheridan, G., Svoboda, H., Viana, M., da F. Costa, L., Guck, J., Holt, C. E. & Franze, K., 19 Sep 2016, In : Nature Neuroscience.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Retinal Ganglion Cells
Ion Channels