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Personal profile

Scholarly biography

Dr. Graham Pattison joined the School of Pharmacy and Biomolecular Sciences at Brighton as Lecturer in Organic Chemistry in September 2018. Before this Graham held a Senior Research Fellowship at the University of Warwick from 2012, where he developed a research programme developing useful new synthetic methods for the preparation of functional molecules, particularly focussing on fluorination of drug-like molecules, organoboron building blocks and catalysis. From 2009-2012, he worked as a postdoc in the lab of Prof. Hon Wai Lam at the University of Edinburgh, where he developed interests in asymmetric catalysis, examining new Rh-catalysed addtion of boronic acids to unusual substrates. He was awarded his PhD from Durham University in 2009, working under the supervision of Prof. Graham Sandford, as well as a first-class MChem degree from Durham awarded in 2005.

Research interests

The Pattison group work on the development of new synthetic methodology which will allow chemists to build useful functional molecules in a way which is simpler, more efficient, safer and more sustainable than currently possible. We work in two main areas:

1) Organofluorine chemistry - Over 25% of all drugs on the market today contain a fluorine atom, yet many fluorination methods are challenging to perform, unpredictable or even dangerous. We seek to develop new methods to introduce fluorine into molecules in a safe, convenient and simple way, and understand reactivity of these systems. We have developed methods for the synthesis of fluorinated ketones, which are useful building-blocks which were difficult to make previously.

2) Organoboron chemistry - Boron provides a useful functional handle to increase the complexity of molecules. Boron can act as a stable building block, which can be readily transformed into new functional groups, or used to construct new C-C bonds in molecular scaffolds. We have developed transition-metal-free couplings of organoboron compounds, including the first examples of homologative coupling of aldehydes and ketones, and a new method for regioselective difunctionalization adjacent to a carbonyl group.

Approach to teaching

I aim to teach students in a way which is accessible and presents complex key concepts in an easy-to-understand, yet comprehensive way. I try to make lectures as interactive as possible, and to give students opportunties to put new material they have learnt into practice.

I am also keen to give opportunities for undergraduate research, and try to allow students to take maximium ownership of a project, in a supportive environment.

Supervisory Interests

Research areas where project applications are welcomed include: 

- Synthetic Methodology Devleopment

- Organofluorine Chemistry

- Organoboron Chemistry

- Catalysis

- Physical Organic Chemistry

- Medicinal Chemistry

- Bioimaging Molecules

Education/Academic qualification

PhD, University of Durham

Master, University of Durham

Keywords

  • QD Chemistry
  • Sustainable synthetic methods
  • Organofluorine chemistry
  • Organoboron chemistry
  • Catalysis
  • Medicinal chemistry

Fingerprint Dive into the research topics where Graham Pattison is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Ketones Chemical Compounds
Fluorine Chemical Compounds
Nucleophiles Chemical Compounds
Rhodium Chemical Compounds
Derivatives Chemical Compounds
Scaffolds Chemical Compounds
Substitution reactions Chemical Compounds
Fluorination Chemical Compounds

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Research Output 2008 2019

A Coupling Approach for the Generation of α,α-Bis(enolate) Equivalents: Regioselective Synthesis of gem-Difunctionalized Ketones

Iacono, C. E., Stephens, T. C., Rajan, T. S. & Pattison, G., 30 Jan 2018, In : Journal of the American Chemical Society. 140, 6, p. 2036-2040 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Gems
Ketones
Boron Compounds
Boron compounds
Transition metals

Transition-Metal-Free Homologative Cross-Coupling of Aldehydes and Ketones with Geminal Bis(boron) Compounds

Stephens, T. C. & Pattison, G., 13 Jun 2017, In : Organic Letters. 19, 13, p. 3498-3501 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Boron Compounds
boron compounds
cross coupling
Ketones
aldehydes

Rh-Catalyzed arylation of fluorinated ketones with arylboronic acids

Dobson, L. S. & Pattison, G., 16 Aug 2016, In : Chemical Communications. 52, 74, p. 11116-11119 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Ketones
Acids
Boronic Acids
Alcohols
Chemical activation

One-pot synthesis of difluoromethyl ketones by a difluorination/fragmentation process

Leng, D. J., Black, C. M. & Pattison, G., 7 Feb 2016, In : Organic and Biomolecular Chemistry. 14, 5, p. 1531-1535 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Ketones
ketones
fragmentation
synthesis
Drug Design

Methods for the Synthesis of α,α-Difluoroketones

Pattison, G., 1 Aug 2018, In : European Journal of Organic Chemistry. 2018, 27, p. 3520-3540 21 p.

Research output: Contribution to journalLiterature reviewResearchpeer-review

Enzyme Inhibitors
synthesis
inhibitors
enzymes
chemistry