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Catalytic Antibodies Chemical Compounds
Haptens Chemical Compounds
Hydrolysis Chemical Compounds
Aziridines Chemical Compounds
Lactams Chemical Compounds
Azides Chemical Compounds
Antibodies Chemical Compounds
Rats Chemical Compounds

Research Output 2002 2007

Evidence that the mechanism of antibody-catalysed hydrolysis of arylcarbamates can be determined by the structure of the immunogen used to elicit the catalytic antibody

Boucher, G., Said, B., Ostler, E., Resmini, M., Brocklehurst, K. & Gallacher, G., Feb 2007, In : Biochemical Journal. 401, 3, p. 721-726 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Catalytic Antibodies
Haptens
Hydrolysis
Antibodies
Phosphates

Evidence for ‘lock and key’ character in an anti-phosphonate hydrolytic antibody catalytic site augmented by non-reaction centre recognition: variation in substrate selectivity between an anti-phosphonate antibody, an anti-phosphate antibody and two hydrolytic enzymes

Sonkaria, S., Boucher, G., Florez-Alvarez, J., Said, B., Hussain, S., Ostler, E., Gul, S., Thomas, E. W., Resmini, M., Gallacher, G. & Brocklehurst, K., Jul 2004, In : Biochemical Journal. 381, 1, p. 125-130 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Improvement in hydrolytic antibody activity by change in haptenic structure from phosphate to phosphonate with retention of a common leaving-group determinant: evidence for the ‘flexibility’ hypothesis

Gul, S., Sonkaria, S., Pinitglang, S., Florez-Alvarez, J., Hussain, S., Thomas, E. W., Ostler, E., Gallacher, G., Resmini, M. & Brocklehurst, K., 2003, In : Biochemical Journal. 376, 3, p. 813-821 9 p.

Research output: Contribution to journalArticleResearchpeer-review

A rat monoclonal antibody that catalyses the hydrolysis of a nitrophenyl-β-lactam

Ostler, E., Dean, C. J., Barber, N., Valeri, M., James, S., Resmini, M., Boucher, G., Romanov, N., Brocklehurst, K. & Gallacher, G., Nov 2002, In : Biochemical and biophysical research communications. 299, 2, p. 273-276 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Lactams
Rats
Hydrolysis
Monoclonal Antibodies
Catalytic Antibodies

Polyclonal antibody-catalysed hydrolysis of a beta-lactam

Ostler, E., Resmini, M., Boucher, G., Romanov, N., Brocklehurst, K. & Gallacher, G., 2002, In : Chemical Communications. 3, p. 226-227 2 p.

Research output: Contribution to journalArticleResearchpeer-review