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Research Output 2007 2019

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2019

Catalytic mechanism of mevalonate kinase revisited, a QM/MM study

McClory, J., Lin, J. T., Timson, D., Zhang, J. & Huang, M., 5 Feb 2019, In : Organic and Biomolecular Chemistry. 17, 9, p. 2423-2431 9 p.

Research output: Contribution to journalArticleResearchpeer-review

mevalonate kinase
Mevalonic Acid
Adenosine Triphosphate
Biofuels
Phosphorylation

Escherichia coli Modulator of Drug Activity B (MdaB) Has Different Enzymological Properties to Eukaryote Quinone Oxidoreductases

Megarity, C. F. & Timson, D. J., 8 Jun 2019, In : Helvetica Chimica Acta.

Research output: Contribution to journalArticleResearchpeer-review

Dicumarol
Eukaryota
Oxidoreductases
Escherichia coli
Alanine

Four Challenges for Better Biocatalysts

Timson, D. J., 9 May 2019, In : Fermentation. 5, 2, 9 p., 39.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Enzymes
Protein folding
Biochemistry
Molecules
Biomolecules

Fructose 1,6-bisphosphatase: getting the message across

Timson, D., 6 Mar 2019, In : Bioscience Reports. 39, 3, p. 1-5 5 p., BSR20190124.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Fructose-Bisphosphatase
Adenosine Monophosphate
Enzymes
Binding Sites
Allosteric Regulation

Myosin Va and spermine synthase: partners in exosome transport

Timson, D., 30 Apr 2019, In : Bioscience Reports. 39, 4, p. 1-5 5 p., BSR20190326.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Spermine Synthase
Exosomes
Myosins
Proteins
Genes

NAD(P)H quinone oxidoreductase (NQO1): An enzyme which needs just enough mobility, in just the right places

Pey, A. L., Megarity, C. F. & Timson, D. J., 3 Jan 2019, In : Bioscience Reports. 39, 1, BSR20180459.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Flavin-Adenine Dinucleotide
NAD
Oxidoreductases
Dicumarol
Quinones

Negative cooperativity in NAD(P)H quinone oxidoreductase 1 (NQO1)

Megarity, C. F., Abdel-Aal Bettley, H., Caraher, M. C., Scott, K. A., Whitehead, R. A., Jowitt, T. A., Gutierrez, A., Bryce, R. A., Nolan, K. A., Stratford, I. J. & Timson, D. J., 5 Jun 2019, In : ChemBioChem.

Research output: Contribution to journalArticleResearchpeer-review

NAD
Oxidoreductases
Dicumarol
Binding Sites
Proteins

Phosphorylation Mechanism of N-acetyl-L-Glutamate Kinase, a QM/MM Study

McClory, J., Hu, G-X., Zou, J-W., Timson, D. J. & Huang, M., 8 Mar 2019, In : Journal of Physical Chemistry B. 123, 13, p. 2844-2852 9 p.

Research output: Contribution to journalArticleResearchpeer-review

glutamate 5-kinase
acetylglutamate kinase
phosphorylation
glutamates
Phosphorylation
2018

A galactokinase-like protein from the liver fluke Fasciola hepatica

Zinsser, V. L., Cox, C., McAuley, M., Hoey, E. M., Trudgett, A. & Timson, D. J., 21 Jul 2018, In : Experimental Parasitology. 192, p. 65-72 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Galactokinase
Fasciola hepatica
Galactose
Acetylgalactosamine
Proteins

Calmodulins from Schistosoma mansoni: biochemical analysis and interaction with IQ-motifs from voltage-gated calcium channels

Thomas, C. M. & Timson, D., 17 May 2018, In : Cell Calcium.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Schistosoma mansoni
Calmodulin
Calcium Channels
Calcium
Ions

Improving the activity and stability of human galactokinase for therapeutic and biotechnological applications

McAuley, M., Mesa-Torres, N., McFall, A., Morris, S., Huang, M., Pey, A. L. & Timson, D., 26 Apr 2018, In : ChemBioChem. 19, 10, p. 1088-1095 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Galactokinase
Human Activities
Enzyme Replacement Therapy
Enzymes
Galactosemias

Modulation of the mobility of a key region in human galactokinase: Impacts on catalysis and stability

McAuley, M., Huang, M. & Timson, D. J., 19 Sep 2018, In : Bioorganic Chemistry. 81, p. 649-657 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Galactokinase
Catalysis
Enzymes
Galactose
Catalytic Domain

The mechanism of action of praziquantel: can new drugs exploit similar mechanisms?

Thomas, C. & Timson, D., 26 Sep 2018, In : Current Medicinal Chemistry. 25, 1

Research output: Contribution to journalArticleResearchpeer-review

Praziquantel
Pharmaceutical Preparations
Calcium Channels
Paralysis
Ions

The tegumental allergen-like proteins of Schistosoma mansoni: a biochemical study of SmTAL4-TAL13

Carson, J., Thomas, C. M., McGinty, A., Takata, G. & Timson, D., 14 Feb 2018, In : Molecular and Biochemical Parasitology. 221, p. 14-22 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Schistosoma mansoni
allergens
ions
hands
proteins

Type IV galactosemia

Timson, D. J., 21 Nov 2018, In : Genetics in Medicine. 21, p. 1283-1285

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Water-mediated network in the resistance mechanism of fosfomycin

McClory, J., Lin, J. T., Timson, D. J., Zhang, J. & Huang, M., 2 Aug 2018, In : Physical Chemistry Chemical Physics. 20, 33, p. 21660-21667 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Fosfomycin
Water
phosphates
phosphorylation
Phosphorylation
2017

Characterisation of eppin function: expression and activity in the lung

Scott, A., Glasgow, A., Small, D., Carlile, S., McCrudden, M. T. C., McLean, D. T. F., Brown, R., Doherty, D., Lundy, F. T., Hamid, U. I., O'Kane, C. M., McAuley, D. F., Brodlie, M., Tunney, M., Elborn, J. S., Irwin, C. R., Timson, D., Taggart, C. C. & Weldon, S., 13 Jul 2017, In : European Respiratory Journal. 50, 1

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Lipopolysaccharides
Myeloid Cells
Lung
Chemokine CXCL2
Serine Proteinase Inhibitors

Different specificities of two aldehyde dehydrogenases from Saccharomyces cerevisiae var boulardii

Datta, S., Annapore, U. S. & Timson, D., 26 Jan 2017, In : Bioscience Reports. 37, 2

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
aldehyde dehydrogenase
aldehydes
Saccharomyces cerevisiae
active sites
isozymes

Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

Medina-Carmona, E., Fuchs, J. E., Gavira, J. A., Mesa-Torres, N., Neira, J. L., Salido, E., Palomino-Morales, R. J., Burgos, M., Timson, D. & Pey, A. L., 6 Jul 2017, In : Human Molecular Genetics. 26, 18, p. 3531-3544 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Proteins
Amino Acids
Mutation
Protein Stability
Genetic Suppression

In silico prediction of the effects of mutations in the human triose phosphate isomerase gene: towards a predictive framework for TPI deficiency

Oliver, C. & Timson, D., 21 Mar 2017, In : European Journal of Medical Genetics. 60, 6, p. 289-298 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Triose-Phosphate Isomerase
Computer Simulation
Mutation
Genes
Amino Acids

LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1 -Rac1 pathway

Carmon, K. S., Xing, G., Yi, J., Wu, L., Thomas, A., Moore, C., Masuho, I., Timson, D., Martemyanov, K. A. & Liu, Q. J., 24 Jul 2017, In : Journal of Biological Chemistry. 292, p. 14989-15001 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cell Adhesion
Colonic Neoplasms
Stem Cells
Actins
Catenins

New model for the interaction of IQGAP1 with CDC42 and RAC1

Nouri, K., Timson, D. & Ahmadian, M. R., 19 Jun 2017, In : Small GTPases.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Proteins
GTP Phosphohydrolases
Adhesion
Polarization

Reaction Mechanism of Isopentenyl Phosphate Kinase: A QM/MM Study

McClory, J., Timson, D., Singh, W., Zhang, J. & Huang, M., 20 Nov 2017, In : Journal of Physical Chemistry B. 121, 49, p. 11062-11071 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Phosphorylation
Phosphotransferases
Phosphates
Substrates
Metal ions

Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism

Medina-Carmona, E., Neira, J. L., Salido, E., Fuchs, J. E., Palomino-Morales, R. J., Timson, D. & Pey, A. L., 14 Mar 2017, In : Scientific Reports. 7

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Flavin-Adenine Dinucleotide
Neoplasms
Inborn Genetic Diseases
Proteins
Prodrugs

UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-6 (pp-GalNAc-T6): Role in cancer and prospects as a drug target

Banford, S. & Timson, D., 1 Jan 2017, In : Current Cancer Drug Targets. 17, 1, p. 53-61 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Acetylgalactosamine
Uridine Diphosphate
Galactosamine
Pharmaceutical Preparations
Neoplasms

We are all mutants

Timson, D., 2017, In : School Science Review. 99, 366, p. 45-50

Research output: Contribution to journalArticleResearchpeer-review

Down Syndrome
science
social science
Disease
cause
2016

A mysterious family of calcium-binding proteins from parasitic worms

Thomas, C. M. & Timson, D. J., 15 Aug 2016, In : Biochemical Society Transactions. 44, 4, p. 1005-1010 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Calcium-Binding Proteins
Helminths
Ions
Calcium
EF Hand Motifs

Antioxidant properties and global metabolite screening ofthe probiotic yeast Saccharomyces cerevisiae var. boulardii

Datta, S., Timson, D. & Annapure, U. S., 21 Nov 2016, In : Journal of the Science of Food and Agriculture. 97, 9, p. 3039-3049 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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probiotics
Saccharomyces cerevisiae
metabolites
yeasts
screening

Calmodulin disruption impacts growth and motility in juvenile liver fluke

Timson, D., 27 Jan 2016, In : Parasites & Vectors. 9, p. 1-13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Fasciola hepatica
Calmodulin
Growth
Calcium
Fasciola

Characterization of Cd36_03230p, a putative vanillin dehydrogenase from Candida dubliniensis

Datta, S., Annapure, U. S. & Timson, D., 14 Oct 2016, In : RSC Advances. 6, 102, p. 99774-99780 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Candida
Aldehyde Dehydrogenase
Substrates
Yeast
CD36 Antigens

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

Medina-Carmona, E., Palomino-Morales, R. J., Fuchs, J. E., Padin-Gonzalez, E., Mesa-Torres, N., Salido, E., Timson, D. & Pey, A. L., 3 Feb 2016, In : Scientific Reports. 6

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Flavin-Adenine Dinucleotide
Pharmacology
Ligands
Neoplasms
Dicumarol

Disturbed cofactor binding by a novel mutation in UDP-galactose 4 '-epimerase results in a type III galactosemia phenotype at birth

Paul, S., McCorvie, T. J., Zschocke, J. & Timson, D., 3 Feb 2016, In : RSC Advances. 6, 21, p. 17297-17301 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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UDPglucose 4-Epimerase
Galactosemias
Galactose
Parturition
Phenotype

Experimental and computational evidence on conformational fluctuations as a source of catalytic defects in genetic diseases

Fuchs, J. E., Munoz, I. G., Timson, D. & Pey, A. L., 13 Jun 2016, In : RSC Advances. 6, 63, p. 58604-58612 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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NAD
Defects
Molecular dynamics
UDPglucose 4-Epimerase
Thermodynamics

Fasciola hepaticacalcium binding protein FhCaBP2: Structure of the dynein light chain-like domain

Nguyen, T. H., Thomas, C. M., Timson, D. & Van Raaij, M. J., 16 Apr 2016, In : Parasitology Research. 115, 7, p. 2879-2886 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Fasciola
Dyneins
Fasciola hepatica
Carrier Proteins
EF Hand Motifs

FhCaBP1 (FH22): a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains

Thomas, C. M., Cheung, S. & Timson, D., 28 Sep 2016, In : Experimental Parasitology. 170, p. 109-115 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Dyneins
Calcium-Binding Proteins
Ions
Calcium
Proteins

Galactokinase promiscuity: A question of flexibility?

McAuley, M., Kristiansson, H., Huang, M., Pey, A. L. & Timson, D. J., 15 Feb 2016, In : Biochemical Society Transactions. 44, p. 116-122 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Galactokinase
Galactosemias
Sugars
Catalytic Domain
Enzymes

Glycerol enhances fungal germination at the water-activity limit for life

Stevenson, A., Hamill, P. G., Medina, A., Kminek, G., Rummel, J. D., Dijksterhuis, J., Timson, D., Magan, N., Leong, S. L. & Hallsworth, J. E., 13 Nov 2016, In : Environmental Microbiology. 19, p. 947-967 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
water activity
glycerol
germination
xerophytes
spores

Insight into the mechanism of galactokinase: role of a critical glutamate residue and helix/coil transitions

McAuley, M., Huang, M. & Timson, D., 24 Oct 2016, In : BBA - Proteins and Proteomics. 1865, 3, p. 321-328 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Galactokinase
Glutamic Acid
Enzymes
Methionine
Galactosemias

IQGAP1 interaction with RHO family proteins revisited: Kinetic andequilibrium evidence for multiple distinct binding sites

Nouri, K., Fansa, E. K., Amin, E., Dvorsky, R., Gremer, L., Willbold, D., Schmitt, L., Timson, D. & Ahmadian, M. R., 4 Nov 2016, In : Journal of Biological Chemistry. 291, 0, p. 26364-26376 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
GTP Phosphohydrolases
Binding Sites
Proteins
Cell Polarity
Guanosine Triphosphate

Metabolic Enzymes of Helminth Parasites: Potential as Drug Targets

Timson, D., 31 Dec 2016, In : Current Protein & Peptide Science. 17, 3, p. 280-295 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Modulating mobility: a paradigm for protein engineering?

McAuley, M. & Timson, D., 23 Jul 2016, In : Applied Biochemistry and Biotechnology. p. 1-8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Proteins
Ligands
Catalysis
Molecular dynamics
Engineers

Natural small molecules as stabilizers and activators of cancer-associated NQO1 polymorphisms

Pey, A. L., Megarity, C. F., Medina-Carmona, E. & Timson, D., 1 Jan 2016, In : Current Drug Targets. 17, 13, p. 1506-1514 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Neoplasms
Pharmacology
Quinones
Protein Stability
NAD

On the Interaction Between Human IQGAP1 and Actin

Magill, D. J., Hamilton, E., Shirran, S. L., Botting, C. H. & Timson, D., 1 Apr 2016, In : Protein and Peptide Letters. 23, 4, p. 386-395 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Actins
Proteins
Static Electricity
Cold Climate
Saccharomyces cerevisiae Proteins

Phosphorylation Mechanism of Phosphomevalonate Kinase: Implications for Rational Engineering of Isoprenoid Biosynthetic Pathway Enzymes

Huang, M., Wei, K., Li, X., McClory, J., Hu, G., Zou, J-W. & Timson, D., 27 Sep 2016, In : Journal of Physical Chemistry B. 120, 41, p. 10714-10722 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Phosphorylation
Terpenes
Mevalonic Acid
Phosphotransferases
Enzymes
2015

Chaotropicity: a key factor in product tolerance of biofuel-producing microorganisms

Cray, J. A., Stevenson, A., Ball, P., Bankar, S. B., Eleutherio, E. C. A., Ezeji, T. C., Singhal, R. S., Thevelein, J. M., Timson, D. & Hallsworth, J. E., 30 Jun 2015, In : Current Opinion in Biotechnology. 33, p. 228-259 32 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparative biochemical analysis of three members of the Schistosoma mansoni TAL family: Differences in ion and drug binding properties

Thomas, C. M., Fitzsimmons, C. M., Timson, D. & Dunne, D. W., 31 Jan 2015, In : Biochimie. 108, p. 40-47 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Dicoumarol: a drug which hits at least two very different targets in vitamin K metabolism

Timson, D., 22 Jul 2015, In : Current Drug Targets. 16, p. 1-11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Dicumarol
Vitamin K
Warfarin
Vitamin K Epoxide Reductases
Pharmaceutical Preparations

FhCaBP2: a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains

Thomas, C. M. & Timson, D., 30 Sep 2015, In : Parasitology. 142, 11, p. 1375-1386 12 p.

Research output: Contribution to journalArticleResearchpeer-review

In Silico Prediction of the Effects of Mutations in the Human Mevalonate Kinase Gene: Towards a Predictive Framework for Mevalonate Kinase Deficiency

Browne, C. & Timson, D., 30 Nov 2015, In : Annals of Human Genetics. 79, 6, p. 451-459 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Is there a common water-activity limit for the three domains of life?

Stevenson, A., Cray, J. A., Williams, J. P., Santos, R., Sahay, R., Neuenkirchen, N., McClure, C. D., Grant, I. R., Houghton, J. D. R. & Timson, D., 30 Jun 2015, In : ISME Journal. 9, 6, p. 1333-1351 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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