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Research Output 2007 2019

2019

A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer

Vankova, P., Salido, E., Timson, D., Man, P. & Pey, A. L., 12 Nov 2019, In : Biomolecules. 9, 11, 728.

Research output: Contribution to journalArticle

Open Access
File
Flavin-Adenine Dinucleotide
Dicumarol
Dimers
Ligands
Communication

Cancer-associated variants of human NQO1: Impacts on inhibitor binding and cooperativity

Megarity, C. F. & Timson, D. J., 6 Sep 2019, In : Bioscience Reports. 39, 9, BSR20191874.

Research output: Contribution to journalArticle

Open Access
File
Dicumarol
Niacinamide
Oxidoreductases
Quinine
Enzymes

Catalytic mechanism of mevalonate kinase revisited, a QM/MM study

McClory, J., Lin, J. T., Timson, D., Zhang, J. & Huang, M., 5 Feb 2019, In : Organic and Biomolecular Chemistry. 17, 9, p. 2423-2431 9 p.

Research output: Contribution to journalArticle

mevalonate kinase
Mevalonic Acid
Adenosine Triphosphate
Biofuels
Phosphorylation

Characterization of Calcium-Binding Proteins from Parasitic Worms

Thomas, C. M. & Timson, D. J., 2 Feb 2019, Calcium-Binding Proteins of the EF-Hand Superfamily. Heizmann, C. (ed.). New York: Humana Press, Vol. 1929. p. 615-641 27 p. (Methods in molecular biology (Clifton, N.J.)).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Calcium-Binding Proteins
Helminths
Calcium Signaling
Helminth Proteins
Pharmaceutical Preparations

Dynamic origins of substrate promiscuity in bacterial galactokinases

McAuley, M., Huang, M. & Timson, D., 17 Oct 2019, In : Carbohydrate Research. 486, 107839.

Research output: Contribution to journalArticle

Enzymes
Escherichia coli
Galactokinase
Sugar Phosphates
Bacterial Structures
Dicumarol
Eukaryota
Oxidoreductases
Escherichia coli
Alanine

Evidence for chaotropicity/kosmotropicity offset in a yeast growth model

Eardley, J., Dedi, C., Dymond, M., Hallsworth, J. E. & Timson, D., 26 Sep 2019, In : Biotechnology Letters. 41, 11, p. 1309-1318 10 p.

Research output: Contribution to journalArticle

yeast
ethanol
ammonium sulfate
fermentation
solute

Four Challenges for Better Biocatalysts

Timson, D. J., 9 May 2019, In : Fermentation. 5, 2, 9 p., 39.

Research output: Contribution to journalArticle

Open Access
File
Enzymes
Protein folding
Biochemistry
Molecules
Biomolecules

Fructose 1,6-bisphosphatase: getting the message across

Timson, D., 6 Mar 2019, In : Bioscience Reports. 39, 3, p. 1-5 5 p., BSR20190124.

Research output: Contribution to journalArticle

Open Access
File
Fructose-Bisphosphatase
Adenosine Monophosphate
Enzymes
Binding Sites
Allosteric Regulation

Myosin Va and spermine synthase: partners in exosome transport

Timson, D., 30 Apr 2019, In : Bioscience Reports. 39, 4, p. 1-5 5 p., BSR20190326.

Research output: Contribution to journalArticle

Open Access
File
Spermine Synthase
Exosomes
Myosins
Proteins
Genes

NAD(P)H quinone oxidoreductase (NQO1): An enzyme which needs just enough mobility, in just the right places

Pey, A. L., Megarity, C. F. & Timson, D. J., 3 Jan 2019, In : Bioscience Reports. 39, 1, BSR20180459.

Research output: Contribution to journalArticle

Open Access
File
Flavin-Adenine Dinucleotide
NAD
Oxidoreductases
Dicumarol
Quinones

Negative cooperativity in NAD(P)H quinone oxidoreductase 1 (NQO1)

Megarity, C. F., Abdel-Aal Bettley, H., Caraher, M. C., Scott, K. A., Whitehead, R. A., Jowitt, T. A., Gutierrez, A., Bryce, R. A., Nolan, K. A., Stratford, I. J. & Timson, D. J., 5 Jun 2019, In : ChemBioChem. 20, 22, p. 2841-2849 9 p.

Research output: Contribution to journalArticle

NAD
Oxidoreductases
Dicumarol
Binding Sites
Proteins

NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms

Beaver, S. K., Mesa-Torres, N., Pey, A. L. & Timson, D. J., 12 May 2019, In : BBA - Proteins and Proteomics. 1867, 7-8, p. 663-676 14 p.

Research output: Contribution to journalReview article

Flavin-Adenine Dinucleotide
NAD
Neoplasms
Proteins
Genetic Suppression

Phosphorylation Mechanism of N-acetyl-L-Glutamate Kinase, a QM/MM Study

McClory, J., Hu, G-X., Zou, J-W., Timson, D. J. & Huang, M., 8 Mar 2019, In : Journal of Physical Chemistry B. 123, 13, p. 2844-2852 9 p.

Research output: Contribution to journalArticle

glutamate 5-kinase
acetylglutamate kinase
phosphorylation
glutamates
Phosphorylation

Repurposing drugs for the treatment of galactosemia

Timson, D., 22 Oct 2019, In : Expert Opinion on Orphan Drugs. 7, 10, p. 443-451 9 p.

Research output: Contribution to journalReview article

Drug Repositioning
Galactosemias
Galactose
Therapeutics
Antioxidants
2018

A galactokinase-like protein from the liver fluke Fasciola hepatica

Zinsser, V. L., Cox, C., McAuley, M., Hoey, E. M., Trudgett, A. & Timson, D. J., 21 Jul 2018, In : Experimental Parasitology. 192, p. 65-72 8 p.

Research output: Contribution to journalArticle

Open Access
File
Galactokinase
Fasciola hepatica
Galactose
Acetylgalactosamine
Proteins
Open Access
File
Schistosoma mansoni
Calmodulin
Calcium Channels
Calcium
Ions

Improving the activity and stability of human galactokinase for therapeutic and biotechnological applications

McAuley, M., Mesa-Torres, N., McFall, A., Morris, S., Huang, M., Pey, A. L. & Timson, D., 26 Apr 2018, In : ChemBioChem. 19, 10, p. 1088-1095 8 p.

Research output: Contribution to journalArticle

Open Access
File
Galactokinase
Human Activities
Enzyme Replacement Therapy
Enzymes
Galactosemias

Modulation of the mobility of a key region in human galactokinase: Impacts on catalysis and stability

McAuley, M., Huang, M. & Timson, D. J., 19 Sep 2018, In : Bioorganic Chemistry. 81, p. 649-657 9 p.

Research output: Contribution to journalArticle

Open Access
File
Galactokinase
Catalysis
Enzymes
Galactose
Catalytic Domain

Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer

Betancor-Fernández, I., Timson, D. J., Salido, E. & Pey, A. L., 1 Jan 2018, Targeting Trafficking in Drug Development. Ulloa-Aguirre, A. & Tao, Y. X. (eds.). Springer, p. 155-190 36 p. (Handbook of Experimental Pharmacology; vol. 245).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Pharmacology
Molecules
Protein Stability
Neoplasms
Proteins

Prenatal alcohol exposure, biomarkers and fetal alcohol spectrum disorders

Gard, P. R., Zanganeh, M. & Timson, D. J., 4 Dec 2018, Fetal Alcohol Syndrome: Recognition, Differential Diagnosis and Long-Term Effects. Nova Science Publishers Inc, p. 19-57 39 p.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Fetal Alcohol Spectrum Disorders
Biomarkers
Alcohols
Histone Code
Mothers

Prenatal Alcohol Exposure, Biomarkers and Foetal Alcohol Spectrum Disorders

Gard, P., Zanganeh, M. & Timson, D., Nov 2018, Fetal Alcohol Syndrome: Recognition, Differential Diagnosis and Long-Term Effects. Knight, D. (ed.). Nova Science Publishers Inc, p. 19-57 38 p.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Fetal Alcohol Spectrum Disorders
Biomarkers
Alcohols
Histone Code
Mothers

The mechanism of action of praziquantel: can new drugs exploit similar mechanisms?

Thomas, C. & Timson, D., 26 Sep 2018, In : Current Medicinal Chemistry. 25, 1

Research output: Contribution to journalArticle

Open Access
File
Praziquantel
Pharmaceutical Preparations
Calcium Channels
Paralysis
Ions

The mechanism of action of praziquantel: Six hypotheses

Thomas, C. M. & Timson, D. J., 1 Jan 2018, In : Current Topics in Medicinal Chemistry. 18, 18, p. 1575-1584 10 p.

Research output: Contribution to journalReview article

Praziquantel
Pharmaceutical Preparations
Anthelmintics
Parasites
Hydra

The tegumental allergen-like proteins of Schistosoma mansoni: a biochemical study of SmTAL4-TAL13

Carson, J., Thomas, C. M., McGinty, A., Takata, G. & Timson, D., 14 Feb 2018, In : Molecular and Biochemical Parasitology. 221, p. 14-22 9 p.

Research output: Contribution to journalArticle

Open Access
File
Schistosoma mansoni
allergens
ions
hands
proteins

Type IV galactosemia

Timson, D. J., 21 Nov 2018, In : Genetics in Medicine. 21, p. 1283-1285

Research output: Contribution to journalArticle

Open Access
File

Water-mediated network in the resistance mechanism of fosfomycin

McClory, J., Lin, J. T., Timson, D. J., Zhang, J. & Huang, M., 2 Aug 2018, In : Physical Chemistry Chemical Physics. 20, 33, p. 21660-21667 8 p.

Research output: Contribution to journalArticle

Open Access
File
Fosfomycin
Water
phosphates
phosphorylation
Phosphorylation
2017

Characterisation of eppin function: expression and activity in the lung

Scott, A., Glasgow, A., Small, D., Carlile, S., McCrudden, M. T. C., McLean, D. T. F., Brown, R., Doherty, D., Lundy, F. T., Hamid, U. I., O'Kane, C. M., McAuley, D. F., Brodlie, M., Tunney, M., Elborn, J. S., Irwin, C. R., Timson, D., Taggart, C. C. & Weldon, S., 13 Jul 2017, In : European Respiratory Journal. 50, 1

Research output: Contribution to journalArticle

Open Access
File
Lipopolysaccharides
Myeloid Cells
Lung
Chemokine CXCL2
Serine Proteinase Inhibitors

Different specificities of two aldehyde dehydrogenases from Saccharomyces cerevisiae var boulardii

Datta, S., Annapore, U. S. & Timson, D., 26 Jan 2017, In : Bioscience Reports. 37, 2

Research output: Contribution to journalArticle

Open Access
File
aldehyde dehydrogenase
aldehydes
Saccharomyces cerevisiae
active sites
isozymes

Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

Medina-Carmona, E., Fuchs, J. E., Gavira, J. A., Mesa-Torres, N., Neira, J. L., Salido, E., Palomino-Morales, R. J., Burgos, M., Timson, D. & Pey, A. L., 6 Jul 2017, In : Human Molecular Genetics. 26, 18, p. 3531-3544 14 p.

Research output: Contribution to journalArticle

Open Access
File
Proteins
Amino Acids
Mutation
Protein Stability
Genetic Suppression
Open Access
File
Triose-Phosphate Isomerase
Computer Simulation
Mutation
Genes
Amino Acids

LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1 -Rac1 pathway

Carmon, K. S., Xing, G., Yi, J., Wu, L., Thomas, A., Moore, C., Masuho, I., Timson, D., Martemyanov, K. A. & Liu, Q. J., 24 Jul 2017, In : Journal of Biological Chemistry. 292, p. 14989-15001 13 p.

Research output: Contribution to journalArticle

Open Access
File
Cell Adhesion
Colonic Neoplasms
Stem Cells
Actins
Catenins

Molecular Genetics of Galactosaemia

Timson, D., 15 May 2017, eLS. Chichester: John Wiley & Sons Ltd

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Galactosemias
Molecular Biology
Genes
UDPglucose 4-Epimerase
Galactokinase

New model for the interaction of IQGAP1 with CDC42 and RAC1

Nouri, K., Timson, D. & Ahmadian, M. R., 19 Jun 2017, In : Small GTPases.

Research output: Contribution to journalArticle

Open Access
File
Proteins
GTP Phosphohydrolases
Adhesion
Polarization

Reaction Mechanism of Isopentenyl Phosphate Kinase: A QM/MM Study

McClory, J., Timson, D., Singh, W., Zhang, J. & Huang, M., 20 Nov 2017, In : Journal of Physical Chemistry B. 121, 49, p. 11062-11071 10 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
Phosphotransferases
Phosphates
Substrates
Metal ions

Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism

Medina-Carmona, E., Neira, J. L., Salido, E., Fuchs, J. E., Palomino-Morales, R. J., Timson, D. & Pey, A. L., 14 Mar 2017, In : Scientific Reports. 7

Research output: Contribution to journalArticle

Open Access
File
Flavin-Adenine Dinucleotide
Neoplasms
Inborn Genetic Diseases
Proteins
Prodrugs
Open Access
File
Acetylgalactosamine
Uridine Diphosphate
Galactosamine
Pharmaceutical Preparations
Neoplasms

We are all mutants

Timson, D., 2017, In : School Science Review. 99, 366, p. 45-50

Research output: Contribution to journalArticle

Down Syndrome
science
social science
Disease
cause
2016

A mysterious family of calcium-binding proteins from parasitic worms

Thomas, C. M. & Timson, D. J., 15 Aug 2016, In : Biochemical Society Transactions. 44, 4, p. 1005-1010 6 p.

Research output: Contribution to journalArticle

Open Access
File
Calcium-Binding Proteins
Helminths
Ions
Calcium
EF Hand Motifs

Antioxidant properties and global metabolite screening ofthe probiotic yeast Saccharomyces cerevisiae var. boulardii

Datta, S., Timson, D. & Annapure, U. S., 21 Nov 2016, In : Journal of the Science of Food and Agriculture. 97, 9, p. 3039-3049 11 p.

Research output: Contribution to journalArticle

Open Access
File
probiotics
Saccharomyces cerevisiae
metabolites
yeasts
screening

Calmodulin disruption impacts growth and motility in juvenile liver fluke

Timson, D., 27 Jan 2016, In : Parasites & Vectors. 9, p. 1-13 13 p.

Research output: Contribution to journalArticle

Open Access
File
Fasciola hepatica
Calmodulin
Growth
Calcium
Fasciola

Characterization of Cd36_03230p, a putative vanillin dehydrogenase from Candida dubliniensis

Datta, S., Annapure, U. S. & Timson, D., 14 Oct 2016, In : RSC Advances. 6, 102, p. 99774-99780 7 p.

Research output: Contribution to journalArticle

Open Access
File
Candida
Aldehyde Dehydrogenase
Substrates
Yeast
CD36 Antigens

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

Medina-Carmona, E., Palomino-Morales, R. J., Fuchs, J. E., Padin-Gonzalez, E., Mesa-Torres, N., Salido, E., Timson, D. & Pey, A. L., 3 Feb 2016, In : Scientific Reports. 6

Research output: Contribution to journalArticle

Open Access
File
Flavin-Adenine Dinucleotide
Pharmacology
Ligands
Neoplasms
Dicumarol

Disturbed cofactor binding by a novel mutation in UDP-galactose 4 '-epimerase results in a type III galactosemia phenotype at birth

Paul, S., McCorvie, T. J., Zschocke, J. & Timson, D., 3 Feb 2016, In : RSC Advances. 6, 21, p. 17297-17301 5 p.

Research output: Contribution to journalArticle

Open Access
File
UDPglucose 4-Epimerase
Galactosemias
Galactose
Parturition
Phenotype

Experimental and computational evidence on conformational fluctuations as a source of catalytic defects in genetic diseases

Fuchs, J. E., Munoz, I. G., Timson, D. & Pey, A. L., 13 Jun 2016, In : RSC Advances. 6, 63, p. 58604-58612 9 p.

Research output: Contribution to journalArticle

Open Access
File
NAD
Defects
Molecular dynamics
UDPglucose 4-Epimerase
Thermodynamics

Fasciola hepaticacalcium binding protein FhCaBP2: Structure of the dynein light chain-like domain

Nguyen, T. H., Thomas, C. M., Timson, D. & Van Raaij, M. J., 16 Apr 2016, In : Parasitology Research. 115, 7, p. 2879-2886 8 p.

Research output: Contribution to journalArticle

Open Access
File
Fasciola
Dyneins
Fasciola hepatica
Carrier Proteins
EF Hand Motifs

FhCaBP1 (FH22): a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains

Thomas, C. M., Cheung, S. & Timson, D., 28 Sep 2016, In : Experimental Parasitology. 170, p. 109-115 7 p.

Research output: Contribution to journalArticle

Open Access
File
Dyneins
Calcium-Binding Proteins
Ions
Calcium
Proteins

Galactokinase promiscuity: A question of flexibility?

McAuley, M., Kristiansson, H., Huang, M., Pey, A. L. & Timson, D. J., 9 Feb 2016, In : Biochemical Society Transactions. 44, p. 116-122 7 p.

Research output: Contribution to journalArticle

Open Access
File
Galactokinase
Galactosemias
Sugars
Catalytic Domain
Enzymes

Glycerol enhances fungal germination at the water-activity limit for life

Stevenson, A., Hamill, P. G., Medina, A., Kminek, G., Rummel, J. D., Dijksterhuis, J., Timson, D., Magan, N., Leong, S. L. & Hallsworth, J. E., 13 Nov 2016, In : Environmental Microbiology. 19, p. 947-967 21 p.

Research output: Contribution to journalArticle

Open Access
File
water activity
glycerol
germination
xerophytes
spores

Insight into the mechanism of galactokinase: role of a critical glutamate residue and helix/coil transitions

McAuley, M., Huang, M. & Timson, D., 24 Oct 2016, In : BBA - Proteins and Proteomics. 1865, 3, p. 321-328 8 p.

Research output: Contribution to journalArticle

Open Access
File
Galactokinase
Glutamic Acid
Enzymes
Methionine
Galactosemias