David Timson

Personal profile

Research interests

David Timson is a protein biochemist. His research focuses on understanding how the structures of proteins influence their functions, with particular relevance to those proteins implicated in human disease and in biotechnology. Current research areas include:

1. Proteins of human galactose metabolism and how they are affected by the inherited metabolic disease, galactosemia.

2. Calcium binding proteins and metabolic enzymes from helminth parasites.

3. Quinone oxidoreductases

4. Stress mitigation in biofuel production

5. The biochemistry underlying fetal alcohol specturm disorders (collaboration led by Prof Paul Gard)

Supervisory Interests

Protein biochemistry including:

1. Quinone oxidoreductases (and their links to cancer and other diseases)

2. Galactose metabolising enzymes (and how they go wrong in galactosemia and how they can be used in biocatalysis)

3. Helminth parasite proteins (and how they can be exploited as drug targets)

Education/Academic qualification

Queen's University Belfast

PhD, University of Birmingham

Bachelor, University of Birmingham

External positions

Editorial Board, Fermentation, MDPI Publishers

Associate Editor, Biosceince Reports, Portland Press

Associate Editor, RSC Advances, Royal Society of Chemistry

Keywords

Q Science (General)
Biochemistry
Molecular Biology
Proteins
Enzymology

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Galactokinase Medicine & Life Sciences

Galactosemias Medicine & Life Sciences

Enzymes Medicine & Life Sciences

Galactose Medicine & Life Sciences

Proteins Medicine & Life Sciences

Fasciola hepatica Medicine & Life Sciences

UDPglucose 4-Epimerase Medicine & Life Sciences

Calmodulin Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2007 2019

72 Article
9 Chapter
2 Review article

Cancer-associated variants of human NQO1: Impacts on inhibitor binding and cooperativity

Megarity, C. F. & Timson, D. J., 6 Sep 2019, In : Bioscience Reports. 39, 9, BSR20191874.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

File

Dicumarol

Niacinamide

Oxidoreductases

Quinine

Enzymes

Catalytic mechanism of mevalonate kinase revisited, a QM/MM study

McClory, J., Lin, J. T., Timson, D., Zhang, J. & Huang, M., 5 Feb 2019, In : Organic and Biomolecular Chemistry. 17, 9, p. 2423-2431 9 p.

Research output: Contribution to journal › Article › Research › peer-review

mevalonate kinase

Mevalonic Acid

Adenosine Triphosphate

Biofuels

Phosphorylation

Characterization of Calcium-Binding Proteins from Parasitic Worms

Thomas, C. M. & Timson, D. J., 2 Feb 2019, Calcium-Binding Proteins of the EF-Hand Superfamily. Heizmann, C. (ed.). New York: Humana Press, Vol. 1929. p. 615-641 27 p. (Methods in molecular biology (Clifton, N.J.)).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBN › Chapter › Research › peer-review

Calcium-Binding Proteins

Helminths

Calcium Signaling

Helminth Proteins

Pharmaceutical Preparations