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Personal profile

Research interests

David Timson is a protein biochemist.  His research focuses on understanding how the structures of proteins influence their functions, with particular relevance to those proteins implicated in human disease and in biotechnology.  Current research areas include:

1.  Proteins of human galactose metabolism and how they are affected by the inherited metabolic disease, galactosemia.

2.  Calcium binding proteins and metabolic enzymes from helminth parasites.

3.  Quinone oxidoreductases

4.  Stress mitigation in biofuel production

5.  The biochemistry underlying fetal alcohol specturm disorders (collaboration led by Prof Paul Gard)

 

Please note:  I have now retired and am unable to undertake active supervision of new projects, since I no longer have a laboratory.  I am happy to advise on these areas and to respond to questions on my papers etc.  This means I am not recruiting postgraduate students or post-docs etc.

Education/Academic qualification

Queen's University Belfast

PhD, University of Birmingham

Bachelor, University of Birmingham

External positions

Editorial Board, Fermentation, MDPI Publishers

Associate Editor, Biosceince Reports, Portland Press

Associate Editor, RSC Advances, Royal Society of Chemistry

Keywords

  • Q Science (General)
  • Biochemistry
  • Molecular Biology
  • Proteins
  • Enzymology

Fingerprint Dive into the research topics where David Timson is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Galactokinase Medicine & Life Sciences
Galactosemias Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Fasciola hepatica Medicine & Life Sciences
Galactose Medicine & Life Sciences
Proteins Medicine & Life Sciences
UDPglucose 4-Epimerase Medicine & Life Sciences
Calmodulin Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2007 2020

Novel and selective inactivators of Triosephosphate isomerase with anti-trematode activity

Ferraro, F., Corvo, I., Bergalli, L., Ilarraz, A., Cabrera, M., Gil, J., Susuki, B. M., Caffrey, C. R., Timson, D. J., Robert, X., Guillon, C., Freire, T. & Álvarez, G., 13 Feb 2020, In : Scientific Reports. 10, 1, 2587.

Research output: Contribution to journalArticle

Open Access
File
Triose-Phosphate Isomerase
Fasciola hepatica
triclabendazole
Trematode Infections
Inhibitory Concentration 50
EF Hand Motifs
Praziquantel
Schistosoma mansoni
Ion Channels
Protein Binding

A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer

Vankova, P., Salido, E., Timson, D., Man, P. & Pey, A. L., 12 Nov 2019, In : Biomolecules. 9, 11, 728.

Research output: Contribution to journalArticle

Open Access
File
Flavin-Adenine Dinucleotide
Dicumarol
Dimers
Ligands
Communication

Cancer-associated variants of human NQO1: Impacts on inhibitor binding and cooperativity

Megarity, C. F. & Timson, D. J., 6 Sep 2019, In : Bioscience Reports. 39, 9, BSR20191874.

Research output: Contribution to journalArticle

Open Access
File
Dicumarol
Niacinamide
Oxidoreductases
Quinine
Enzymes

Catalytic mechanism of mevalonate kinase revisited, a QM/MM study

McClory, J., Lin, J. T., Timson, D., Zhang, J. & Huang, M., 5 Feb 2019, In : Organic and Biomolecular Chemistry. 17, 9, p. 2423-2431 9 p.

Research output: Contribution to journalArticle

Open Access
File
mevalonate kinase
Mevalonic Acid
Adenosine Triphosphate
Biofuels
Phosphorylation

Activities 2004 2019

Pharmaceutical Society of Ireland (PSI) (External organisation)

David Timson (Member)
2019 → …

Activity: External boards and professional/academic bodiesPersonal board membership of professional/academic bodies

PhD external examination

David Timson (Examiner)
2017

Activity: External examination and supervisionResearch degree

Higher Education Academy, UK (External organisation)

David Timson (Fellow)
2017 → …

Activity: External boards and professional/academic bodiesMembership of professional body

Royal Society of Chemistry (External organisation)

David Timson (Fellow)
2016 → …

Activity: External boards and professional/academic bodiesMembership of professional body

RSC Advances (Journal)

David Timson (Member of editorial board)
2015 → …

Activity: Publication peer-review and editorial workEditorial work