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Personal profile

Research interests

David Timson is a protein biochemist.  His research focuses on understanding how the structures of proteins influence their functions, with particular relevance to those proteins implicated in human disease and in biotechnology.  Current research areas include:

1.  Proteins of human galactose metabolism and how they are affected by the inherited metabolic disease, galactosemia.

2.  Calcium binding proteins and metabolic enzymes from helminth parasites.

3.  Quinone oxidoreductases

4.  Stress mitigation in biofuel production

5.  The biochemistry underlying fetal alcohol specturm disorders (collaboration led by Prof Paul Gard)

Supervisory Interests

Protein biochemistry including:

1. Quinone oxidoreductases (and their links to cancer and other diseases)

2. Galactose metabolising enzymes (and how they go wrong in galactosemia and how they can be used in biocatalysis)

3. Helminth parasite proteins (and how they can be exploited as drug targets)

Education/Academic qualification

Queen's University Belfast

PhD, University of Birmingham

Bachelor, University of Birmingham

External positions

Editorial Board, Fermentation

Associate Editor, Biosceince Reports

Associate Editor, RSC Advances, Royal Society of Chemistry

Keywords

  • Q Science (General)
  • Biochemistry
  • Molecular Biology
  • Proteins
  • Enzymology

Fingerprint Dive into the research topics where David Timson is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Galactokinase Medicine & Life Sciences
Galactosemias Medicine & Life Sciences
Galactose Medicine & Life Sciences
Proteins Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Fasciola hepatica Medicine & Life Sciences
UDPglucose 4-Epimerase Medicine & Life Sciences
Calmodulin Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2007 2019

Catalytic mechanism of mevalonate kinase revisited, a QM/MM study

McClory, J., Lin, J. T., Timson, D., Zhang, J. & Huang, M., 5 Feb 2019, In : Organic and Biomolecular Chemistry. 17, 9, p. 2423-2431 9 p.

Research output: Contribution to journalArticleResearchpeer-review

mevalonate kinase
Mevalonic Acid
Adenosine Triphosphate
Biofuels
Phosphorylation

Characterization of Calcium-Binding Proteins from Parasitic Worms

Thomas, C. M. & Timson, D. J., 2 Feb 2019, Calcium-Binding Proteins of the EF-Hand Superfamily. Heizmann, C. (ed.). New York, Vol. 1929. p. 615-641 27 p. (Methods in molecular biology (Clifton, N.J.)).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapterResearchpeer-review

Calcium-Binding Proteins
Helminths
Calcium Signaling
Helminth Proteins
Pharmaceutical Preparations

Escherichia coli Modulator of Drug Activity B (MdaB) has different enzymological properties to eukaryote quinone oxidoreducatases

Megarity, C. F. & Timson, D. J., 8 Jun 2019, In : Helvetica Chimica Acta.

Research output: Contribution to journalArticleResearchpeer-review

Dicumarol
Eukaryota
Escherichia coli
Alanine
Glycine

Four Challenges for Better Biocatalysts

Timson, D. J., 9 May 2019, In : Fermentation. 5, 2, 9 p., 39.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Enzymes
Protein folding
Biochemistry
Molecules
Biomolecules

Fructose 1,6-bisphosphatase: getting the message across

Timson, D., 6 Mar 2019, In : Bioscience Reports. 39, 3, p. 1-5 5 p., BSR20190124.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Fructose-Bisphosphatase
Adenosine Monophosphate
Enzymes
Binding Sites
Allosteric Regulation

Activities 2004 2017

  • 6 Membership of professional body
  • 1 Research degree
  • 1 Personal board membership of professional/academic bodies
  • 1 Visiting an external academic institution

Higher Education Academy, UK (External organisation)

David Timson (Chair)
2017 → …

Activity: External boards and professional/academic bodiesMembership of professional body

PhD external examination

David Timson (Examiner)
2017

Activity: External examination and supervisionResearch degree

Royal Society of Chemistry (External organisation)

David Timson (Chair)
2016 → …

Activity: External boards and professional/academic bodiesMembership of professional body

Queen's University Belfast

David Timson (Visiting researcher)
20152018

Activity: Visiting positionVisiting an external academic institution

Biochemical Society (External organisation)

David Timson (Chair)
20132016

Activity: External boards and professional/academic bodiesPersonal board membership of professional/academic bodies