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Research Output 2014 2019

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2019

Genome-wide analysis of the role of the antibiotic biosynthesis regulator AbsA2 in Streptomyces coelicolor A3(2)

Lewis, R., Wahab, A., Bucca, G., Laing, E. E., Moller-Levet, C., Kierzek, A. & Smith, C., 10 Apr 2019, In : PLoS ONE. 14, 4, p. 1-23 23 p., e0200673.

Research output: Contribution to journalArticle

Open Access
File
Streptomyces coelicolor
antibiotics
biosynthesis
Genome
Anti-Bacterial Agents

Stress hormone-mediated acceleration of breast cancer metastasis is halted by inhibition of nitric oxide synthase

Flaherty, R. L., Intabli, H., Falcinelli, M., Bucca, G., Hesketh, A., Patel, B., Allen, M., Smith, C. & Flint, M., 24 May 2019, In : Cancer Letters. 459, p. 59-71 13 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase
Hormones
Breast Neoplasms
Neoplasm Metastasis
Glucocorticoids
2018

Personal Genome Project UK (PGP-UK): a research and citizen science hybrid project in support of personalized medicine

Personal Genome Project UK (PGP UK) & Smith, C., 27 Nov 2018, In : BMC Medical Genomics. 11, 12 p., 108.

Research output: Contribution to journalArticle

Open Access
File
Precision Medicine
Genome
Research
Genomics
Information Dissemination

Translational control plays an important role in the adaptive heat-shock response of Streptomyces coelicolor

Bucca, G., Pothi, R., Hesketh, A., Moller-Levet, C., Hodgson, D. A., Laing, E. E., Stewart, G. R. & Smith, C., 9 May 2018, In : Nucleic Acids Research. 46, 11, p. 5692–5703

Research output: Contribution to journalArticle

Open Access
File
Streptomyces coelicolor
Heat-Shock Response
Polyribosomes
Hot Temperature
Molecular Chaperones
2017

Daily supplementation with 15 μg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial

Tripkovic, L., Wilson, L., Hart, K., Johnsen, S., de Lusignan, S., Smith, C., Bucca, G., Penson, S., Chope, G. & Elliott, R., 5 Jul 2017, In : American Journal of Clinical Nutrition. 106, 2, p. 481-490 10 p.

Research output: Contribution to journalArticle

Open Access
File
Ergocalciferols
Cholecalciferol
Placebos
Food
Vitamin D
2016

OsdR of Streptomyces coelicolor and the Dormancy Regulator DevR of Mycobacterium tuberculosis Control Overlapping Regulons

Urem, M., Rossum, T. V., Bucca, G., Moolenaar, G. F., Laing, E., Swiatek-Polatynska, M. A., Willemse, J., Tenconi, E., Regali, S., Goosen, N., Smith, C. & Wezel, G. P. V., 3 May 2016, In : mSystems. 1, 3

Research output: Contribution to journalArticle

Open Access
File
Streptomyces coelicolor
Regulon
Mycobacterium tuberculosis
Genes
Phosphotransferases

The dynamic transcriptional and translational landscape of the model antibiotic producer Streptomyces coelicolor A3(2)

Jeong, Y., Kim, J-N., Kim, M. W., Bucca, G., Cho, S., Yoon, Y. J., Kim, B-G., Roe, J-H., Kim, S. C., Smith, C. & Cho, B-K., 2 Jun 2016, In : Nature Communications. 7, 11605.

Research output: Contribution to journalArticle

Open Access
File
Streptomyces coelicolor
transcription (genetics)
antibiotics
harness
genome
2015

Exploiting human and mouse transcriptomic data: Identification of circadiangenes and pathways influencing health

Laing, E., Johnston, J. D., Moller-Levet, C., Bucca, G., Smith, C., Dijk, D-J. & Archer, S. N., 14 Mar 2015, In : Bioessays. 37, 5, p. 544-556 13 p.

Research output: Contribution to journalArticle

Open Access
File
Sleep
Health
Computational Biology
Cytoplasmic and Nuclear Receptors
Circadian Rhythm

Genome-wide analysis of in vivo binding of the master regulator DasR in Streptomyces coelicolor identifies novel non-canonical targets

Swiatek-Polatynska, M. A., Bucca, G., Laing, E., Gubbens, J., Titgemeyer, F., Smith, C., Rigali, S. & Wezel, G. P. V., 15 Apr 2015, In : PLoS ONE. 10, 4

Research output: Contribution to journalArticle

Open Access
File
Streptomyces coelicolor
Acetylglucosamine
Genome
Secondary Metabolism
Regulon
2014

A comparison of key aspects of gene regulation in Streptomyces coelicolor and Escherichia coli using nucleotide-resolution transcription maps produced in parallel by global and differential RNA sequencing

Romero, D. A., Hasan, A. H., Lin, Y., Kime, L., Ruiz-Larrabeiti, O., Urem, M., Bucca, G., Mamanova, L., Laing, E. & Smith, C., 27 Oct 2014, In : Molecular Microbiology. 94, 5, p. 963-987 25 p.

Research output: Contribution to journalArticle

Open Access
File
Streptomyces coelicolor
RNA Sequence Analysis
Nucleotides
RNA Stability
Escherichia coli

A terD Domain-Encoding Gene (SCO2368) Is Involved in Calcium Homeostasis and Participates in Calcium Regulation of a DosR-Like Regulon in Streptomyces coelicolor

Daigle, F., Lerat, S., Sanssouci, E., Smith, C., Malouin, F. & Beaulieu, C., 22 Dec 2014, In : Journal of Bacteriology. 197, 5, p. 913-923 11 p.

Research output: Contribution to journalArticle

Streptomyces coelicolor
regulon
dormancy
homeostasis
calcium

Deciphering the regulon of Streptomyces coelicolor AbrC3, a positiveresponse regulator of antibiotic production

Rico, S., Santamaria, R. I., Yepes, A., Laing, E., Bucca, G., Smith, C. & Diaz, M., 7 Feb 2014, In : Applied and Environmental Microbiology. 80, 8, p. 2417-2428 12 p.

Research output: Contribution to journalArticle

Open Access
File
Streptomyces coelicolor
Regulon
Genetic Promoter Regions
Anti-Bacterial Agents
Chromatin Immunoprecipitation

Mistimed sleep disrupts circadian regulation of the human transcriptome

Archer, S. N., Laing, E., Moller-Levet, C., van der Veen, D. R., Bucca, G., Lazar, A. S., Santhi, N., Slak, A., Kabiljo, R. & Smith, C., 21 Jan 2014, In : Proceedings of the National Academy of Sciences. 111, 6

Research output: Contribution to journalArticle

Transcriptome
Sleep
Periodicity
Circadian Rhythm
Chromatin