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Personal profile

Scholarly biography

Genomics has been at the heart of Colin Smith’s research for the last 18 years and he has engaged in range of interdisciplinary collaborations, investigating antibiotic production by bacteria, human sleep and human nutrition. His first degree, in Microbiology, was undertaken at the University of Bristol and his PhD was awarded for research at the John Innes Centre (Norwich, UK) where he studied the regulation of gene expression in antibiotic producing bacteria. He is presently focusing on how antibiotic production is controlled at the level of translation and how vitamin D influences human gene expression.He is currently a member of the Centre for Stress and Age-Related Disease (STRAND) and these projects are outlined in the Cell Biology section STRAND's web pages.

He joined the University of Brighton in 2016 to establish Brighton Genomics and to bring genomics approaches to new interdisciplinary collaborations across Brighton’s research institutions and other UK universities. He is a strong advocate of personal genomics and had his whole genome sequenced in 2013. Colin is the first person to have donated his genome sequence under ‘open consent’ to the Personal Genome Project UK.

Colin was the lead organiser of a prestigious Royal Society international scientific meeting in March 2018 entitled ‘Changing views of translation: from ribosome profiling to high resolution imaging of single molecules in vivo’. This meeting brought together leading researchers from across the world who study gene expression at two ends of the spectrum – from, on the one hand, global analysis of translation of all genes in cells and tissues to, on the other hand, analysis of expression of single molecules using new high resolution imaging techniques. The bringing together of scientists from these two fields helped facilitate the development of new collaborations and approaches aimed at understanding how cellular processes are co-ordinated within cells.

Fingerprint Dive into the research topics where Colin Smith is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Streptomyces coelicolor Medicine & Life Sciences
Regulon Medicine & Life Sciences
Genome Medicine & Life Sciences
Transcriptome Medicine & Life Sciences
Sleep Medicine & Life Sciences
Anti-Bacterial Agents Medicine & Life Sciences
Genes Medicine & Life Sciences
antibiotics Agriculture & Biology

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Research Output 2014 2019

Genome-wide analysis of the role of the antibiotic biosynthesis regulator AbsA2 in Streptomyces coelicolor A3(2)

Lewis, R., Wahab, A., Bucca, G., Laing, E. E., Moller-Levet, C., Kierzek, A. & Smith, C., 10 Apr 2019, In : PLoS ONE. 14, 4, p. 1-23 23 p., e0200673.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Streptomyces coelicolor
Anti-Bacterial Agents

Stress hormone-mediated acceleration of breast cancer metastasis is halted by inhibition of nitric oxide synthase

Flaherty, R. L., Intabli, H., Falcinelli, M., Bucca, G., Hesketh, A., Patel, B., Allen, M., Smith, C. & Flint, M., 24 May 2019, In : Cancer Letters. 459, p. 59-71 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitric Oxide Synthase
Breast Neoplasms
Neoplasm Metastasis

Personal Genome Project UK (PGP-UK): a research and citizen science hybrid project in support of personalized medicine

Smith, C., 27 Nov 2018, In : BMC Medical Genomics. 11, 12 p., 108.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Precision Medicine
Information Dissemination

Translational control plays an important role in the adaptive heat-shock response of Streptomyces coelicolor

Bucca, G., Pothi, R., Hesketh, A., Moller-Levet, C., Hodgson, D. A., Laing, E. E., Stewart, G. R. & Smith, C., 9 May 2018, In : Nucleic Acids Research. 46, 11, p. 5692–5703

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Streptomyces coelicolor
Heat-Shock Response
Hot Temperature
Molecular Chaperones

Daily supplementation with 15 µg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial

Tripkovic, L., Wilson, L., Hart, K., Johnsen, S., de Lusignan, S., Smith, C., Bucca, G., Penson, S., Chope, G. & Elliott, R., 5 Jul 2017, In : American Journal of Clinical Nutrition. 106, 2, p. 481-490 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Vitamin D