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Personal profile

Scholarly biography

Genomics has been at the heart of Colin Smith’s research for the last 18 years and he has engaged in range of interdisciplinary collaborations, investigating antibiotic production by bacteria, human sleep and human nutrition. His first degree, in Microbiology, was undertaken at the University of Bristol and his PhD was awarded for research at the John Innes Centre (Norwich, UK) where he studied the regulation of gene expression in antibiotic producing bacteria. He is presently focusing on how antibiotic production is controlled at the level of translation and how vitamin D influences human gene expression.He is currently a member of the Centre for Stress and Age-Related Disease (STRAND) and these projects are outlined in the Cell Biology section STRAND's web pages.

He joined the University of Brighton in 2016 to establish Brighton Genomics and to bring genomics approaches to new interdisciplinary collaborations across Brighton’s research institutions and other UK universities. He is a strong advocate of personal genomics and had his whole genome sequenced in 2013. Colin is the first person to have donated his genome sequence under ‘open consent’ to the Personal Genome Project UK.

Colin was the lead organiser of a prestigious Royal Society international scientific meeting in March 2018 entitled ‘Changing views of translation: from ribosome profiling to high resolution imaging of single molecules in vivo’. This meeting brought together leading researchers from across the world who study gene expression at two ends of the spectrum – from, on the one hand, global analysis of translation of all genes in cells and tissues to, on the other hand, analysis of expression of single molecules using new high resolution imaging techniques. The bringing together of scientists from these two fields helped facilitate the development of new collaborations and approaches aimed at understanding how cellular processes are co-ordinated within cells.

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Research Output 2014 2018

Open Access
File
Precision Medicine
Genome
Research
Genomics
Information Dissemination

Translational control plays an important role in the adaptive heat-shock response of Streptomyces coelicolor

Bucca, G., Pothi, R., Hesketh, A., Moller-Levet, C., Hodgson, D. A., Laing, E. E., Stewart, G. R. & Smith, C. 9 May 2018 46, 11, p. 5692–5703

Research output: Contribution to journalArticle

Open Access
File
Streptomyces coelicolor
Heat-Shock Response
Polyribosomes
Hot Temperature
Molecular Chaperones

Daily supplementation with 15 µg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial

Tripkovic, L., Wilson, L., Hart, K., Johnsen, S., de Lusignan, S., Smith, C., Bucca, G., Penson, S., Chope, G. & Elliott, R. 5 Jul 2017 106, 2, p. 481-490 10 p.

Research output: Contribution to journalArticle

Open Access
File
Ergocalciferols
Cholecalciferol
Placebos
Food
Vitamin D

OsdR of Streptomyces coelicolor and the Dormancy Regulator DevR of Mycobacterium tuberculosis Control Overlapping Regulons

Urem, M., Rossum, T. V., Bucca, G., Moolenaar, G. F., Laing, E., Swiatek-Polatynska, M. A., Willemse, J., Tenconi, E., Regali, S., Goosen, N., Smith, C. & Wezel, G. P. V. 3 May 2016 1, 3

Research output: Contribution to journalArticle

Open Access
File
Streptomyces coelicolor
Regulon
Mycobacterium tuberculosis
Genes
Phosphotransferases

The dynamic transcriptional and translational landscape of the model antibiotic producer Streptomyces coelicolor A3(2)

Jeong, Y., Kim, J-N., Kim, M. W., Bucca, G., Cho, S., Yoon, Y. J., Kim, B-G., Roe, J-H., Kim, S. C., Smith, C. & Cho, B-K. 2 Jun 2016 7

Research output: Contribution to journalArticle

Open Access
File
Streptomyces coelicolor
transcription (genetics)
antibiotics
harness
genome