Research Output 2017 2019

2019

Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping

Lane, R., Simon, T., Vintu, M., Solkin, B., Koch, B., Stewart, N., Benstead-Hume, G., Pearl, F., Critchley, G., Stebbing, J. & Giamas, G., 19 Aug 2019, In : Communications Biology. 2, 1, 315.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Glioblastoma
Biomarkers
Neoplasms
Stromal Cells
Extracellular Vesicles

Cilantro leaf harbors a potent potassium channel-activating anticonvulsant

Manville, R. & Abbott, G., 1 Oct 2019, In : The FASEB Journal. 33, 10, p. 11349-11363 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Coriandrum
Potassium Channels
Anticonvulsants
Protein Isoforms
Voltage-Gated Potassium Channels
High performance liquid chromatography
Kynurenine
Metabolism
Tryptophan
Tissue

Direct oral anticoagulant (DOAC)-mediated vasodilation: Role of nitric oxide

Mabley, J., Patel, J., Sayed, A., Arya, R. & Scutt, G., 12 Feb 2019, In : Thrombosis Research. 176, p. 36-38 3 p.

Research output: Contribution to journalLetterResearchpeer-review

Vasodilation
Anticoagulants
Nitric Oxide
Vitamin K
Food-Drug Interactions

Drug diffusion along an intact mammalian cochlea

Sadreev, I. I., Burwood, G. W. S., Flaherty, S. M., Kim, J., Russell, I. J., Abdullin, T. I. & Lukashkin, A. N., 26 Apr 2019, In : Frontiers in Cellular Neuroscience. 13, 161.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Cochlea
Salicylates
Pharmaceutical Preparations
Perilymph
Membranes

Evidence for chaotropicity/kosmotropicity offset in a yeast growth model

Eardley, J., Dedi, C., Dymond, M., Hallsworth, J. E. & Timson, D., 26 Sep 2019, In : Biotechnology Letters. p. 1-10

Research output: Contribution to journalArticleResearchpeer-review

yeast
ethanol
ammonium sulfate
fermentation
solute

Exercise Induced cardiac troponin elevation: An update on the evidence, mechanism and implications

Baker, P., Leckie, T., Harrington, D. & Richardson, A., 14 Mar 2019, In : International Journal of Cardiology: Heart & Vasculature. 22, p. 181-186 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Troponin
Exercise
Chest Pain
Acute Coronary Syndrome
Decision Making

Fructose 1,6-bisphosphatase: getting the message across

Timson, D., 6 Mar 2019, In : Bioscience Reports. 39, 3, p. 1-5 5 p., BSR20190124.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Fructose-Bisphosphatase
Adenosine Monophosphate
Enzymes
Binding Sites
Allosteric Regulation

Green synthesis of Pluronic stabilized reduced graphene oxide: Chemical and biological characterization

Cherian, R., Sandeman, S., Ray, S., Savina, I., Ashtami, J. & Mohanan, PV., 25 Mar 2019, In : Colloids and Surfaces B: Biointerfaces. 179, 19, p. 94-106 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Poloxamer
Graphite
Oxides
Toxicity
Poisons

Heat tolerance of Fire Service Instructors

Watkins, E. R., Hayes, M., Watt, P. & Richardson, A. J., 16 Mar 2019, In : Journal of Thermal Biology. 82, p. 1-9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

teachers
heat tolerance
Fires
heat
signs and symptoms (animals and humans)

High Sensitivity Troponin T in Marathon Runners, Marathon Runners with Heart Disease and Collapsed Marathon Runners

Leckie, T., Richardson, A., Watkins, E., Fitzpatrick, D., Galloway, R., Grimaldi, R., Roberts, A. & Baker, P., 21 Jan 2019, In : Scandinavian Journal of Medicine & Science in Sports. 29, 5, p. 663-668 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Troponin T
Heart Diseases
Control Groups
Troponin
Running

Method of Food Preparation Influences Blood Glucose Response to a High-carbohydrate Meal

Hodges, C., Archer, F., Chowdhury, M., Evans, B. L., Ghelani, D. J., Mortoglou, M. & Guppy, F. M., 10 Oct 2019

Research output: Other contributionResearch

NAD(P)H quinone oxidoreductase (NQO1): An enzyme which needs just enough mobility, in just the right places

Pey, A. L., Megarity, C. F. & Timson, D. J., 3 Jan 2019, In : Bioscience Reports. 39, 1, BSR20180459.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Flavin-Adenine Dinucleotide
NAD
Oxidoreductases
Dicumarol
Quinones

Nutritional pastilles for dietary supplementation

Sarker, D., 2019

Research output: Other contributionResearchpeer-review

schoolchild
science
school

Offensive waste valorisation in the UK: Assessment of the potentials for absorbent hygiene product (AHP) recycling

Takaya, C., Cooper, I., Berg, M., Brittle, S., Muir, R. & Sarker, D., 20 Mar 2019, In : Waste Management. 88, p. 56-70 15 p.

Research output: Contribution to journalArticleResearchpeer-review

hygiene
recycling
plastic
product
packaging waste

Poly(lactic) acid/carbon nanotube composite microneedle arrays for dermal biosensing

Skaria, E., Patel, B., Flint, M. & Ng, K. W., 14 Mar 2019, In : Analtical Chemistry. 91, 7, p. 4436-4443 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Carbon Nanotubes
Voltammetry
Skin
Biosensors
Fabrication

Recycling of Medical Waste Conference

Sarker, D., 2019

Research output: Non-textual outputExhibitionResearch

Industry

Region specific differences in the effect of propofol on the murine colon result in dysmotility

Diss, L., Villeneuve, S., Pearce, K., Yeoman, M. & Patel, B., 29 Mar 2019, In : Autonomic Neuroscience-Basic & Clinical. 219, p. 19-24 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Propofol
Colon
Maintenance
Intravenous Anesthetics
Nitric Oxide Synthase

Repurposing drugs for the treatment of galactosemia

Timson, D., 2019, In : Expert Opinion on Orphan Drugs.

Research output: Contribution to journalArticleResearchpeer-review

Drug Repositioning
Galactosemias
Galactose
Therapeutics
Antioxidants

REST: An epigenetic regulator of neuronal stress responses in the young and ageing brain

Mampay, M. & Sheridan, G. K., 17 Apr 2019, In : Frontiers in Neuroendocrinology. 53, 100744.

Research output: Contribution to journalLiterature reviewResearchpeer-review

Transcriptional Silencer Elements
Epigenomics
Transcription Factors
Brain
Gene Expression

Stress and drug resistance in cancer

Flaherty, R., Falcinelli, M. & Flint, M., 27 Jun 2019, In : Cancer Drug resistance. 2

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Psychological Stress
Drug Resistance
Glucocorticoids
Hormones
Drug Therapy

Stress hormone-mediated acceleration of breast cancer metastasis is halted by inhibition of nitric oxide synthase

Flaherty, R. L., Intabli, H., Falcinelli, M., Bucca, G., Hesketh, A., Patel, B., Allen, M., Smith, C. & Flint, M., 24 May 2019, In : Cancer Letters. 459, p. 59-71 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitric Oxide Synthase
Hormones
Breast Neoplasms
Neoplasm Metastasis
Glucocorticoids

Three-Dimensional-Printed Electrochemical Sensor for Simultaneous Dual Monitoring of Serotonin Overflow and Circular Muscle Contraction

Bin Hamzah, H., Keattch, O., Yeoman, M., Covill, D. & Patel, B., 27 Aug 2019, In : Analytical Chemistry.

Research output: Contribution to journalArticleResearchpeer-review

Electrochemical sensors
Muscle
Serotonin
Monitoring
Sensors

Unprecedented Thiacalixarene Fucoclusters as Strong Inhibitors of Ebola cis-Cell Infection and HCMV-gB Glycoprotein/DC-SIGN C-type Lectin Interaction

Taouai, M., Porkolab, V., Chakroun, K., Cheneau, C., Luczkowiak, J., Abidi, R., Lesur, D., Cragg, P., Halary, F., Delgado, R., Fieschi, F. & Benazza, M., 26 Mar 2019, In : Bioconjugate Chemistry. 30, 4, p. 1114-1126 13 p.

Research output: Contribution to journalArticleResearchpeer-review

C-Type Lectins
Glycoproteins
Viruses
Calixarenes
Ligands

Women firefighters' health and well-being: An international survey

Watkins, E., Walker, A., Mol, E., Jahnke, S. & Richardson, A., 28 Mar 2019, In : Women's Health Issues. 29, 5, p. 424-431 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Firefighters
Women's Health
well-being
conditioning
health
biology
students
lipids
membranes
proteins
2018

3D printable conductive materials for the fabrication of electrochemical sensors: A mini review

Bin Hamzah, H., Shafiee, S. A., Abdalla, A. & Patel, B., 13 Sep 2018, In : Electrochemistry Communications. 96, p. 27-31 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Conductive materials
Electrochemical sensors
3D printers
Fabrication
Printing

Alterations in melatonin and serotonin signalling in the colonic mucosa of mice with dextran-sodium sulfate-induced colitis

MacEachern, S. J., Keenan, C. M., Papakonstantinou, E., Sharkey, K. A. & Patel, B., 25 Mar 2018, In : British Journal of Pharmacology. 175, 9, p. 1535-1547

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Dextran Sulfate
Melatonin
Colitis
Serotonin
Mucous Membrane

Altitude training in endurance running: perceptions of elite athletes and support staff

Turner, G., Fudge, B., Pringle, J. S. M., Maxwell, N. & Richardson, A., 22 Jun 2018, In : Journal of Sports Sciences.

Research output: Contribution to journalArticleResearchpeer-review

Athletes
Altitude Sickness
Practice Guidelines
Internet
Research

Amine-Functionalized Electrically Conductive Core–Sheath MEH-PPV:PCL Electrospun Nanofibers for Enhanced Cell–Biomaterial Interactions

Borah, R., Ingavle, G., Sandeman, S., Kumar, A. & Mikhalovsky, S., 14 Aug 2018, In : ACS Biomaterials Science & Engineering. 4, 9, p. 3327–3346 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Nanofibers
Amines
1,6-diaminohexane
Collagen
Scaffolds (biology)

Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket

Manville, R. & Abbott, G., 21 Sep 2018, In : Nature Communications. 9, 3845.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
KCNQ Potassium Channels
Anticonvulsants
Protein Isoforms
Seizures
Voltage-Gated Potassium Channels

A new occupational heat tolerance test: A feasibility study

Watkins, E. R., Gibbons, J., Dellas, Y., Hayes, M., Watt, P. & Richardson, A. J., 5 Sep 2018, In : Journal of Thermal Biology. 78, p. 42-50 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Feasibility Studies
heat tolerance
Protective Clothing
protective clothing
heat

An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology

Bading Taika, B., Bouckandou, M., Souza, A., Bourobou Bourobou, H. P., Mackenzie, L. & Lione, L. A., 2 Jan 2018, In : Journal of Ethnopharmacology. 216, p. 203-228 26 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Gabon
Toxicology
Pharmacology
Hyperglycemia
Tabernaemontana
Open Access
File
Oils
Mechanical properties
Water
Air
Molecules
File
Biomedical Technology Assessment
Constipation
Drug Prescriptions
Immunologic Factors
Ulcerative Colitis

Bioinspired detoxification of blood: The efficient removal of anthrax toxin protective antigen using an extracorporeal macroporous adsorbent device

Ingavle, G., Baillie, L. W. J., Davies, N., Beaton, N., Zheng, Y., Mikhalovsky, S. & Sandeman, S., 14 May 2018, In : Scientific Reports. 8

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Equipment and Supplies
Hemoperfusion
Antibodies
Monoclonal Antibodies
Exotoxins

Calmodulins from Schistosoma mansoni: biochemical analysis and interaction with IQ-motifs from voltage-gated calcium channels

Thomas, C. M. & Timson, D., 17 May 2018, In : Cell Calcium.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Schistosoma mansoni
Calmodulin
Calcium Channels
Calcium
Ions

Changes in murine anorectum signaling across the life course

Fidalgo, S., Patel, B., Ranson, R., Saffrey, J. & Yeoman, M., 30 Jul 2018, In : Neurogastroenterology and Motility. 30, 10, p. 13426-13438 13 p., e13426.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Fecal Impaction
Acetylcholine
Constipation
Cholinergic Agents
Nitric Oxide

Comparison of Binding Affinities of Water-Soluble Calixarenes with the Organophosphorus Nerve Agent Soman (GD) and Commonly-Used Nerve Agent Simulants

Ede, J. A., Cragg, P. & Sambrook, M., 19 Jan 2018, In : Molecules. 23, 1

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Calixarenes
Chemical Warfare Agents
Soman
Molecular mechanics
Water

Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation

De Silva, A., Manville, R. & Abbott, G., 14 Nov 2018, In : Science Advances Today. 4, 11, eaav0824.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
African Traditional Medicine
Potassium Channels
Traditional Medicine
Voltage-Gated Potassium Channels
Myeloma Proteins

Does the 5-HT1A rs6295 polymorphism influence the safetyand efficacy of citalopram therapy in the oldest old?

Scutt, G., Overall, A., Scott, R., Patel, B., Hachoumi, L., Yeoman, M. & Wright, J., 23 Apr 2018, In : Therapeutic Advances in Drug Safety. 9, 7, p. 355-366

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Citalopram
Genotype
Major Depressive Disorder
Bayes Theorem
Antidepressive Agents

Drop impact onto attached metallic meshes: liquid penetration and spreading

Boscariol, C., Chandra, S., Sarker, D., Crua, C. & Marengo, M., 20 Nov 2018, In : Experiments in Fluids. 59, 12, 189.

Research output: Contribution to journalArticleResearchpeer-review

mesh
penetration
porosity
impact velocity
Liquids

Drop impact onto suspended and surface-attached metallic meshes: liquid penetration and spreading

Boscariol, C., Sarker, D., Chandra, S., Crua, C. & Marengo, M., 26 Jul 2018, p. 0-0. 1 p.

Research output: Contribution to conferencePaperResearchpeer-review

Open Access
File

Electrically conductive MEH-PPV: PCL electrospun nanofibres for electrical stimulation of rat PC12 pheochromocytoma cells

Borah, R., Ingavle, G., Sandeman, S., Kumar, A. & Mikhalovsky, S., 9 Jul 2018, In : Biomaterials Science. 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Nanofibers
PC12 Cells
Pheochromocytoma
Electric Stimulation
Electric Conductivity

Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites

Lund, M. L., Egerod, K. L., Engelstoft, M. S., Dmytriyeva, O., Theodorsson, E., Patel, B. & Schwartz, T. W., 10 Mar 2018, In : Molecular Metabolism.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Glucagon-Like Peptide 1
Serotonin
Enteroendocrine Cells
Small Intestine
Food

Fire Service Instructors' Working Practices: A UK Survey

Watkins, E., Hayes, M., Watt, P. & Richardson, A., 4 May 2018, In : Archives of Environmental & Occupational Health.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Firefighters
Health
Surveys and Questionnaires
Guidelines
Respiration

Hydrazides of glycine-containing decasubstituted pillar[5]arenes: Synthesis and encapsulation of Floxuridine

Shurpik, D., Sevastyanov, D., Zelenikhin, P., Subakaeva, E., Cragg, P., Evtugyn, V., Osin, Y. & Stoikov, I., 31 Oct 2018, In : Tetrahedron Letters. 59, 50, p. 4410–4415 6 p.

Research output: Contribution to journalArticleResearchpeer-review

IL-7 unveils pathogen-specific T cells by enhancing antigen-recall responses

Terrazzini, N., Mantegani, P., Kern, F., Fortis, C., Mondino, A. & Caserta, S., 28 Feb 2018, In : Journal of Infectious Diseases. 217, 12, p. 1997–2007

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Interleukin-7
T-Lymphocytes
Antigens
Blood Cells
Adoptive Immunotherapy

Implementation and evaluation of flipped learning for delivery of analytical chemistry topics

Ponikwer, F. & Patel, B., 12 Feb 2018, In : Analytical and Bioanalytical Chemistry. 410, 9, p. 2263–2269

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
chemistry
evaluation
learning
classroom
teaching method

Improving the activity and stability of human galactokinase for therapeutic and biotechnological applications

McAuley, M., Mesa-Torres, N., McFall, A., Morris, S., Huang, M., Pey, A. L. & Timson, D., 26 Apr 2018, In : ChemBioChem. 19, 10, p. 1088-1095 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Galactokinase
Human Activities
Enzyme Replacement Therapy
Enzymes
Galactosemias