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The Centre for Stress and Age-Related Disease comprises internationally recognised researchers that work on multidisciplinary projects at the biology-chemistry interface, to understand the role played by stress in the initiation and progression of age-related disease and to improve health and wellbeing in older people.

 The centre is unique in the UK; it has scientific expertise in examining the impact that a range of stressors (psychological, xenobiotic, oxidative and mechanical) have on the initiation and progression of age-related disease.

 Research takes advantage of the multi- and inter-disciplinary academic staff, with much of our research being conducted at the biology/chemistry interface, generating novel datasets and attracting significant  funding.

 A multidisciplinary approach allows us to not only understand the involvement of a range of stressors in disease initiation and progression but also allows us to develop novel ways of diagnosing and preventing disease. Our members collaborate locally, nationally and internationally with other academic institutions, charities, hospitals and businesses.

Our work focuses on three main areas of research: Chemical Biology, Cell Biology and Translational Science.

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Group members at Brighton and Sussex Medical School:

Professor Gordon Ferns, Professor of Medical Education and Metabolic Medicine

Professor Pietro Ghezzi, RM Phillips Chair in Experimental Medicine

Dr Snezana Levic, Lecturer in Physiology

Dr Lisa Mullen, Lecturer in Biochemistry

Dr Sandra Sacre, Senior Lecturer in Molecular Cell Biology

 

 

 

Fingerprint Dive into the research topics where Centre for Stress and Age-Related Disease is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

Chemical Warfare Agents Chemical Compounds
Serotonin Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Hot Temperature Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Nitric Oxide Synthase Medicine & Life Sciences
Nitric Oxide Medicine & Life Sciences
Soman Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2015 2020

Research Output 2017 2019

Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping

Lane, R., Simon, T., Vintu, M., Solkin, B., Koch, B., Stewart, N., Benstead-Hume, G., Pearl, F., Critchley, G., Stebbing, J. & Giamas, G., 19 Aug 2019, In : Communications Biology. 2, 1, 315.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Glioblastoma
Biomarkers
Neoplasms
Stromal Cells
Extracellular Vesicles

Cilantro leaf harbors a potent potassium channel-activating anticonvulsant

Manville, R. & Abbott, G., 1 Oct 2019, In : The FASEB Journal. 33, 10, p. 11349-11363 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Coriandrum
Potassium Channels
Anticonvulsants
Protein Isoforms
Voltage-Gated Potassium Channels
High performance liquid chromatography
Kynurenine
Metabolism
Tryptophan
Tissue

Activities 1996 2019

Centre for Stress and Age-Related Disease Outreach Event

Mark Yeoman (Participant)
4 Apr 2019

Activity: EventsOutreach and Public Engagement

Alzheimer's Research UK

Mark Yeoman (Participant)
31 Jan 2019

Activity: EventsOutreach and Public Engagement

Is impaired mucosal signalling responsible for age-related changes in lower bowel function

Mark Yeoman (Presenter)
30 Jan 2019

Activity: External talk or presentationInvited talk