Applied Biosciences Research and Enterprise Group

Research Output

2020

Galactosemia: opportunities for novel therapies

McCorvie, T. J. & Timson, D. J., 19 Feb 2020, Protein Homeostasis Diseases. Pey, A. L. (ed.). Academic Press, p. 221-245 25 p.

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

In Silico Analysis of the Effects of Point Mutations on α-Globin: Implications for α-Thalassemia

Horri-Naceur, A. & Timson, D. J., 18 May 2020, In : Hemoglobin.

Research output: Contribution to journalArticle

Novel and selective inactivators of Triosephosphate isomerase with anti-trematode activity

Ferraro, F., Corvo, I., Bergalli, L., Ilarraz, A., Cabrera, M., Gil, J., Susuki, B. M., Caffrey, C. R., Timson, D. J., Robert, X., Guillon, C., Freire, T. & Álvarez, G., 13 Feb 2020, In : Scientific Reports. 10, 1, 2587.

Research output: Contribution to journalArticle

Open Access
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Praziquantel: An Enigmatic, Yet Effective, Drug

Timson, D. J., 26 May 2020, Schistosoma mansoni: Methods and Protocols. Timson, D. J. (ed.). New York, NY: Springer US, p. 1-8 8 p. (Methods in Molecular Biology ; vol. 2151).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1

Salido, E., Timson, D. J., Betancor-Fernández, I., Palomino-Morales, R. & Pey, A. L., 18 Mar 2020

Research output: Other contribution

Open Access
File

Therapies for galactosemia: a patent landscape

Timson, D. J., 21 Apr 2020, In : Pharmaceutical Patent Analyst.

Research output: Contribution to journalArticle

2019

A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer

Vankova, P., Salido, E., Timson, D., Man, P. & Pey, A. L., 12 Nov 2019, In : Biomolecules. 9, 11, 728.

Research output: Contribution to journalArticle

Open Access
File

Dynamic origins of substrate promiscuity in bacterial galactokinases

McAuley, M., Huang, M. & Timson, D., 17 Oct 2019, In : Carbohydrate Research. 486, 107839.

Research output: Contribution to journalArticle

Evidence for chaotropicity/kosmotropicity offset in a yeast growth model

Eardley, J., Dedi, C., Dymond, M., Hallsworth, J. E. & Timson, D., 26 Sep 2019, In : Biotechnology Letters. 41, 11, p. 1309-1318 10 p.

Research output: Contribution to journalArticle

Fructose 1,6-bisphosphatase: getting the message across

Timson, D., 6 Mar 2019, In : Bioscience Reports. 39, 3, p. 1-5 5 p., BSR20190124.

Research output: Contribution to journalArticle

Open Access
File

Repurposing drugs for the treatment of galactosemia

Timson, D., 22 Oct 2019, In : Expert Opinion on Orphan Drugs. 7, 10, p. 443-451 9 p.

Research output: Contribution to journalReview article

2018

A galactokinase-like protein from the liver fluke Fasciola hepatica

Zinsser, V. L., Cox, C., McAuley, M., Hoey, E. M., Trudgett, A. & Timson, D. J., 21 Jul 2018, In : Experimental Parasitology. 192, p. 65-72 8 p.

Research output: Contribution to journalArticle

Open Access
File
Open Access
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Engineering of TIMP‐3 as a LAP‐fusion protein for targeting to sites of inflammation

Alberts, B., Sacre, S., Bush, P. & Mullen, L., 18 Nov 2018, In : Journal of Cellular and Molecular Medicine. 5 p.

Research output: Contribution to journalArticle

Open Access
File

Improving the activity and stability of human galactokinase for therapeutic and biotechnological applications

McAuley, M., Mesa-Torres, N., McFall, A., Morris, S., Huang, M., Pey, A. L. & Timson, D., 26 Apr 2018, In : ChemBioChem. 19, 10, p. 1088-1095 8 p.

Research output: Contribution to journalArticle

Open Access
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Modulation of the mobility of a key region in human galactokinase: Impacts on catalysis and stability

McAuley, M., Huang, M. & Timson, D. J., 19 Sep 2018, In : Bioorganic Chemistry. 81, p. 649-657 9 p.

Research output: Contribution to journalArticle

Open Access
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Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer

Betancor-Fernández, I., Timson, D. J., Salido, E. & Pey, A. L., 1 Jan 2018, Targeting Trafficking in Drug Development. Ulloa-Aguirre, A. & Tao, Y. X. (eds.). Springer, p. 155-190 36 p. (Handbook of Experimental Pharmacology; vol. 245).

Research output: Chapter in Book/Conference proceeding with ISSN or ISBNChapter

Targeting tumour associated macrophages in anti-cancer therapies

Gal, A., 5 Jan 2018, p. 0-0. 1 p.

Research output: Contribution to conferenceOther

The mechanism of action of praziquantel: can new drugs exploit similar mechanisms?

Thomas, C. & Timson, D., 26 Sep 2018, In : Current Medicinal Chemistry. 25, 1

Research output: Contribution to journalArticle

Open Access
File

The tegumental allergen-like proteins of Schistosoma mansoni: a biochemical study of SmTAL4-TAL13

Carson, J., Thomas, C. M., McGinty, A., Takata, G. & Timson, D., 14 Feb 2018, In : Molecular and Biochemical Parasitology. 221, p. 14-22 9 p.

Research output: Contribution to journalArticle

Open Access
File

Water-mediated network in the resistance mechanism of fosfomycin

McClory, J., Lin, J. T., Timson, D. J., Zhang, J. & Huang, M., 2 Aug 2018, In : Physical Chemistry Chemical Physics. 20, 33, p. 21660-21667 8 p.

Research output: Contribution to journalArticle

Open Access
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