Applied Biosciences Research and Enterprise Group

Organization profile

Profile Information

The Applied Biosciences Research and Enterprise Group encompasses a broad range of multidisciplinary research interests including protein biochemistry and biotechnology, medical microbiology, mechanisms of disease and education for promotion of health and wellbeing.

The group has access to state-of-the-art facilities and is comprised of experienced academics, early career researchers and students working within and beyond the School of Pharmacy and Biomolecular Sciences with national and international collaborators of industry, healthcare and academia to boost research potential and translational impact.

Current specific research investigates the proteins from pathogens, focussing on calcium binding proteins, metabolic enzymes and cytoskeletal components, the engineering of enzymes for biocatalytic purposes, especially sugar kinases and oxidoreductases, the microbial stress biochemistry, including applications to biofuels, the mycobiome of chronic wounds and its impact on wound healing, the epidemiology of unusual and endemic neglected fungal diseases, the diagnostics and point-of-care testing in microbiology, the cryopreservation of articular cartilage, aiming to advance osteoarthritis treatment, the cellular mechanisms of bone lengthening, the role of small non-coding microRNAs in osteosarcoma, and the tumour microenvironment, including the intercellular communication between tumour associated macrophages, cancer associated fibroblasts and tumour cells. Additional research covers the development of learning and teaching strategies and education interventions, for example addressing organ donation and transplantation, to empower student learners, foster inclusive practice, and promote the health and wellbeing of the community.

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Galactokinase Medicine & Life Sciences
Praziquantel Medicine & Life Sciences
Tissue Inhibitor of Metalloproteinase-3 Medicine & Life Sciences
Schistosoma mansoni Medicine & Life Sciences
Calcium Channels Medicine & Life Sciences
Proteins Medicine & Life Sciences
Fasciola hepatica Medicine & Life Sciences
Galactose Medicine & Life Sciences

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Research Output 2018 2018

A galactokinase-like protein from the liver fluke Fasciola hepatica

Zinsser, V. L., Cox, C., McAuley, M., Hoey, E. M., Trudgett, A. & Timson, D. J. 21 Jul 2018 192, p. 65-72 8 p.

Research output: Contribution to journalArticle

Galactokinase
Fasciola hepatica
Galactose
Acetylgalactosamine
Proteins
Schistosoma mansoni
Calmodulin
Calcium Channels
Calcium
Ions

Engineering of TIMP‐3 as a LAP‐fusion protein for targeting to sites of inflammation

Alberts, B., Sacre, S., Bush, P. & Mullen, L. 18 Nov 2018 5 p.

Research output: Contribution to journalArticle

Open Access
File
Tissue Inhibitor of Metalloproteinase-3
Protein Transport
Inflammation
Peptides
Matrix Metalloproteinases